ID   YH10_YEAST              Reviewed;         341 AA.
AC   P38893; D3DLF9;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Uncharacterized isomerase YHR210C;
DE            EC=5.-.-.-;
GN   OrderedLocusNames=YHR210C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- SIMILARITY: Belongs to the aldose epimerase family. {ECO:0000305}.
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DR   EMBL; U00029; AAB69737.1; -; Genomic_DNA.
DR   EMBL; AY558296; AAS56622.1; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06903.1; -; Genomic_DNA.
DR   PIR; S48991; S48991.
DR   RefSeq; NP_012080.3; NM_001179341.3.
DR   AlphaFoldDB; P38893; -.
DR   SMR; P38893; -.
DR   BioGRID; 36644; 57.
DR   STRING; 4932.YHR210C; -.
DR   MaxQB; P38893; -.
DR   PaxDb; P38893; -.
DR   PRIDE; P38893; -.
DR   DNASU; 856617; -.
DR   EnsemblFungi; YHR210C_mRNA; YHR210C; YHR210C.
DR   GeneID; 856617; -.
DR   KEGG; sce:YHR210C; -.
DR   SGD; S000001253; YHR210C.
DR   VEuPathDB; FungiDB:YHR210C; -.
DR   eggNOG; KOG1604; Eukaryota.
DR   GeneTree; ENSGT00510000047589; -.
DR   HOGENOM; CLU_031753_3_0_1; -.
DR   InParanoid; P38893; -.
DR   OMA; AVHPCSG; -.
DR   BioCyc; YEAST:G3O-31235-MON; -.
DR   PRO; PR:P38893; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38893; protein.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0033499; P:galactose catabolic process via UDP-galactose; IBA:GO_Central.
DR   GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR018052; Ald1_epimerase_CS.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   Pfam; PF01263; Aldose_epim; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Isomerase; Reference proteome.
FT   CHAIN           1..341
FT                   /note="Uncharacterized isomerase YHR210C"
FT                   /id="PRO_0000197448"
FT   ACT_SITE        175
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10126"
FT   ACT_SITE        306
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         70
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         239
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  37933 MW;  836E6475D3D4A1B4 CRC64;
     MSNNKAGGEY EVITIGDAKK LQATISELGA TLLDLKVNNE SIVLGYPDIH GYISDGYNYI
     GATVGRYANR IYKGMFSMED GPHQLTVNNC GNTNHSSISS FHLKKYKASK VQNPLDDLYI
     VEFTLLDDRT LPNEFPGDLA VNLKYTLNVA DMTLDLEYEA KLVSGEATPI NMTNHTYFNL
     NKTMDKKSIS GTEVRLCSDK SLEVSEGALI PTGKIVQRKI ATFDSSKPTI LQDDGPIYDY
     AFIVDENKNL KTTDSVSVNK LVPAFKAYHP ASRLSLEVST TEPTVLFYTG DNLCDGFTPR
     SGFAVEQGRY VDAINRDGWR DCVLLRRGEV YTSKTRYRFA V