ID   YH24_CAEEL              Reviewed;         522 AA.
AC   Q27245;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Putative aminopeptidase W07G4.4;
DE            EC=3.4.11.-;
GN   Name=lap-2; ORFNames=W07G4.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M17 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z78018; CAB01448.1; -; Genomic_DNA.
DR   PIR; T26276; T26276.
DR   RefSeq; NP_506260.1; NM_073859.4.
DR   AlphaFoldDB; Q27245; -.
DR   SMR; Q27245; -.
DR   BioGRID; 44809; 19.
DR   STRING; 6239.W07G4.4; -.
DR   World-2DPAGE; 0011:Q27245; -.
DR   World-2DPAGE; 0020:Q27245; -.
DR   EPD; Q27245; -.
DR   PaxDb; Q27245; -.
DR   PeptideAtlas; Q27245; -.
DR   EnsemblMetazoa; W07G4.4.1; W07G4.4.1; WBGene00002250.
DR   GeneID; 179790; -.
DR   KEGG; cel:CELE_W07G4.4; -.
DR   UCSC; W07G4.4; c. elegans.
DR   CTD; 179790; -.
DR   WormBase; W07G4.4; CE03794; WBGene00002250; lap-2.
DR   eggNOG; KOG2597; Eukaryota.
DR   GeneTree; ENSGT00530000063255; -.
DR   HOGENOM; CLU_013734_0_1_1; -.
DR   InParanoid; Q27245; -.
DR   OMA; GEHPAMP; -.
DR   OrthoDB; 562530at2759; -.
DR   PhylomeDB; Q27245; -.
DR   PRO; PR:Q27245; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00002250; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00433; Peptidase_M17; 1.
DR   InterPro; IPR011356; Leucine_aapep/pepB.
DR   InterPro; IPR000819; Peptidase_M17_C.
DR   PANTHER; PTHR11963; PTHR11963; 1.
DR   Pfam; PF00883; Peptidase_M17; 1.
DR   PRINTS; PR00481; LAMNOPPTDASE.
DR   PROSITE; PS00631; CYTOSOL_AP; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Hydrolase; Metal-binding; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..522
FT                   /note="Putative aminopeptidase W07G4.4"
FT                   /id="PRO_0000165854"
FT   ACT_SITE        283
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        358
FT                   /evidence="ECO:0000255"
FT   BINDING         271
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         276
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         276
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         294
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         354
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         356
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         356
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   522 AA;  56089 MW;  BBB82ADF613B8E58 CRC64;
     MSLQSLLSTK IVRATSIADA AFDAVVLVGS QDNVQQFGAI QQVSAIAPAV NNFLKLHSGA
     FNSTSLVQVD SSVVPSGRLI LSGTGNVSRD YDDVRRYQAA ARKGISMALS AGVKSPLLIT
     LPNSRFPNAE LVAALGALTP VYTPLNVREE ENKQKLNQLG LLAIGNSDTS ARLEKLVEAY
     DASFTVCRDV GEAGPERMAP PRVAEYIQGA FANGNIKVTV VDDQSVILKD FPLMAAVNRA
     ANCVKEHQAR LIRLEYVGEG ETQDTFFVVG KGVTIDTGGC DLKTGGHMFG MCRDKYGSAV
     VGGFFKAIDV LKPKNIKAVG YMCMVRNSIG SHAYTCDEVI TSRSGKRIHI YNTDAEGRLT
     MLDPLTLAKE EALNAKNPHL FTVATLTGHE VLSYGYYAAI MDNGPAKASG WARRVQNVGD
     EFGQPIEISR LHPEDFAFHM AECEQADLRQ GNTKPSVATL RGHQTPAAFL QMASRIDEHG
     TNSSHPLKYS HIDMGGCSGD HPSVSFPNPL VTLVAGLVLP HV