YH2M_CAEEL
ID YH2M_CAEEL Reviewed; 1256 AA.
AC Q27533;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Probable cation-transporting ATPase W08D2.5;
DE EC=7.2.2.-;
GN ORFNames=W08D2.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000305}.
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DR EMBL; Z70271; CAA94236.2; -; Genomic_DNA.
DR PIR; T26283; T26283.
DR RefSeq; NP_001255430.1; NM_001268501.1.
DR AlphaFoldDB; Q27533; -.
DR SMR; Q27533; -.
DR BioGRID; 42926; 1.
DR IntAct; Q27533; 1.
DR MINT; Q27533; -.
DR STRING; 6239.W08D2.5a; -.
DR EPD; Q27533; -.
DR PaxDb; Q27533; -.
DR EnsemblMetazoa; W08D2.5a.1; W08D2.5a.1; WBGene00012341.
DR GeneID; 177822; -.
DR KEGG; cel:CELE_W08D2.5; -.
DR UCSC; W08D2.5; c. elegans.
DR CTD; 177822; -.
DR WormBase; W08D2.5a; CE32950; WBGene00012341; catp-6.
DR eggNOG; KOG0208; Eukaryota.
DR GeneTree; ENSGT00940000168207; -.
DR InParanoid; Q27533; -.
DR OMA; GFKFYED; -.
DR OrthoDB; 172453at2759; -.
DR PhylomeDB; Q27533; -.
DR Reactome; R-CEL-936837; Ion transport by P-type ATPases.
DR PRO; PR:Q27533; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00012341; Expressed in adult organism and 4 other tissues.
DR ExpressionAtlas; Q27533; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:WormBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR GO; GO:0005774; C:vacuolar membrane; ISS:WormBase.
DR GO; GO:0015417; F:ABC-type polyamine transporter activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0140358; F:P-type transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:1902047; P:polyamine transmembrane transport; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IGI:WormBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; -; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF12409; P5-ATPase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR SUPFAM; SSF81653; SSF81653; 1.
DR SUPFAM; SSF81660; SSF81660; 1.
DR SUPFAM; SSF81665; SSF81665; 1.
DR TIGRFAMs; TIGR01494; ATPase_P-type; 2.
DR TIGRFAMs; TIGR01657; P-ATPase-V; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Magnesium; Membrane; Metal-binding; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1256
FT /note="Probable cation-transporting ATPase W08D2.5"
FT /id="PRO_0000046358"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..413
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..939
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 940..960
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 961..965
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 966..986
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 987..1002
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1003..1023
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1024..1047
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1048..1068
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1069..1086
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1087..1107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1108..1121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1122..1142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1143..1256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1232..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 465
FT /note="4-aspartylphosphate intermediate"
FT /evidence="ECO:0000250"
FT BINDING 880
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 884
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1256 AA; 140902 MW; CC2DE9F6AE3AECA3 CRC64;
MTLESGDHTL TLFAYRTGPF RTILFYALTV LTLGIFRLIL HWKQKWDVKM RMVPCTFEAA
EYIYIIDNHN VSELQPVLRK SNATIPTENG EMRKVPELRW FVYRKLEYVW IDDLNSDESV
DEISDNDNCW KTSFEIANRI PCRSLLAVSE SNFGLTLSEI SRRLEFYGRN EIVVQLRPIL
YLLVMEVITP FYVFQIFSVT VWYNDEYAYY ASLIVILSLG SIVMDVYQIR TQEIRLRSMV
HSTESVEVIR EGTEMTIGSD QLVPGDILLI PPHGCLMQCD SVLMNGTVIV NESVLTGESV
PITKVALTDE TNDSVFNIEK NSKNVLFCGT QVLQTRFYRG KKVKAIVLRT AYSTLKGQLV
RSIMYPKPVD FRFTKDLFKF ILFLACISGC GFIYTIIVMI MRGNTLRRII VRSLDIITIT
VPPALPAAMS VGIINAQLRL KKKEIFCISP STINTCGAIN VVCFDKTGTL TEDGLDFHVV
RPVMSAVNQE IQKVKLEKSN RTEFMGEMTE LTSRNGLPFD GDLVKAIATC HSLTRINGVL
HGDPLDLILF QKTGWTMEEG IEGDIEEETQ RFDNVQPSII KPTDDKSAEY SVIRQFTFSS
SLQRMSVIVF DPREDRPDNM MLYSKGSPEM ILSLCDPNTV PEDYLLQVNS YAQHGFRLIA
VARRPLDLNF NKASKVKRDA VECDLEMLGL IVMENRVKPV TLGVINQLNR ANIRTVMVTG
DNLLTGLSVA RECGIIRPSK RAFLVEHVPG ELDEYGRTKI FVKQSVSSSD EVIEDDASVS
ISMCSSTWKG SSEGDGFSPT NTEVETPNPV TADSLGHLIA SSYHLAISGP TFAVIVHEYP
ELVDQLCSVC DVFARMAPDQ KQSLVEQLQQ IDYTVAMCGD GANDCAALKA AHAGISLSDA
EASIAAPFTS KVPDIRCVPT VISEGRAALV TSFGIFKYMA GYSLTQFVTV MHLYWISNIL
TDGQFMYIDM FLITMFALLF GNTPAFYRLA HTPPPTRLLS IASMTSVVGQ LIIIGVVQFI
VFFSTSQQPW FTPYQPPVDD EVEDKRSMQG TALFCVSMFQ YIILALVYSK GPPFRGNLWS
NKPMCALTIF ATLLCLFIVI WPTELVLKTL GNVELPSLTF RIFIVIVGAV NAAVSYGFET
LFVDFFLLGY WERYKKKRSI EAIIDYVPTT NSDHIRRPSI NGVTSSRTES TLLSAEGQQL
HMTTSKNGKG GENPHSSALF ERLISRIGGE PTWLTNPIPP HSLSEPEEPE KLERTY
