ID   YHAK_ECO57              Reviewed;         233 AA.
AC   P58115;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Pirin-like protein YhaK;
GN   Name=yhaK; OrderedLocusNames=Z4460, ECs3988;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=26727373; DOI=10.1371/journal.ppat.1005359;
RA   Connolly J.P., Gabrielsen M., Goldstone R.J., Grinter R., Wang D.,
RA   Cogdell R.J., Walker D., Smith D.G., Roe A.J.;
RT   "A highly conserved bacterial D-serine uptake system links host metabolism
RT   and virulence.";
RL   PLoS Pathog. 12:E1005359-E1005359(2016).
CC   -!- FUNCTION: Does not have quercetin 2,3-dioxygenase activity.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Induced under conditions that maximally induce expression of
CC       the large pathogenicity island (PAI) also called the locus of
CC       effacement (LEE). {ECO:0000269|PubMed:26727373}.
CC   -!- DISRUPTION PHENOTYPE: No effect on protein secretion by the type III
CC       secretion system (TTSS) encoded in the locus of effacement (LEE).
CC       {ECO:0000269|PubMed:26727373}.
CC   -!- SIMILARITY: Belongs to the pirin family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved His residues required for metal binding.
CC       Its function must therefore be different from the metal-dependent roles
CC       proposed for other family members. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58239.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37411.1; -; Genomic_DNA.
DR   PIR; C85972; C85972.
DR   PIR; D91127; D91127.
DR   RefSeq; NP_312015.1; NC_002695.1.
DR   RefSeq; WP_000633573.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P58115; -.
DR   SMR; P58115; -.
DR   STRING; 155864.EDL933_4329; -.
DR   EnsemblBacteria; AAG58239; AAG58239; Z4460.
DR   EnsemblBacteria; BAB37411; BAB37411; ECs_3988.
DR   GeneID; 916176; -.
DR   KEGG; ece:Z4460; -.
DR   KEGG; ecs:ECs_3988; -.
DR   PATRIC; fig|386585.9.peg.4162; -.
DR   eggNOG; COG1741; Bacteria.
DR   HOGENOM; CLU_064194_1_0_6; -.
DR   OMA; KADYGWL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR012093; Pirin.
DR   InterPro; IPR003829; Pirin_N_dom.
DR   InterPro; IPR041602; Quercetinase_C.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR43212; PTHR43212; 1.
DR   Pfam; PF02678; Pirin; 1.
DR   Pfam; PF17954; Pirin_C_2; 1.
DR   PIRSF; PIRSF006232; Pirin; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..233
FT                   /note="Pirin-like protein YhaK"
FT                   /id="PRO_0000214062"
SQ   SEQUENCE   233 AA;  25935 MW;  5D2FE570A57773AF CRC64;
     MITTRTARQC GQADYGWLQA RYTFSFGHYF DPKLLGYASL RVLNQEVLAP GAAFQPRTYP
     KVDILNVILD GEAEYRDSEG NHVQASAGEA LLLSTQPGVS YSEHNLSKDK PLTRMQLWLD
     ACPQRENPLI QKLALNMGKQ HLIASPEGAM GSLQLRQQVW LHHIVLDKGE SANFQLHGPR
     TYLQSIHGKF HALTHHEEKA ALTCGDGAFI RDEANITLVA DSPLRALLID LPV