ID   YHAM_ECO57              Reviewed;         436 AA.
AC   Q8XAF6; Q7AAM1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=UPF0597 protein YhaM {ECO:0000255|HAMAP-Rule:MF_01845};
GN   Name=yhaM {ECO:0000255|HAMAP-Rule:MF_01845};
GN   OrderedLocusNames=Z4462, ECs3990;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=26727373; DOI=10.1371/journal.ppat.1005359;
RA   Connolly J.P., Gabrielsen M., Goldstone R.J., Grinter R., Wang D.,
RA   Cogdell R.J., Walker D., Smith D.G., Roe A.J.;
RT   "A highly conserved bacterial D-serine uptake system links host metabolism
RT   and virulence.";
RL   PLoS Pathog. 12:E1005359-E1005359(2016).
CC   -!- FUNCTION: Thought to be a D-serine dehydratase, however it does not
CC       complement a dsdA (D-serine dehydratase) mutant in strain CFT073,
CC       suggesting it may not have that function (PubMed:26727373).
CC       {ECO:0000269|PubMed:26727373}.
CC   -!- INDUCTION: 40-fold induced under conditions that maximally induce
CC       expression of the large pathogenicity island (PAI) also called the
CC       locus of effacement (LEE); part of the dlsT-yhaM operon. Slightly
CC       induced by D-serine. {ECO:0000269|PubMed:26727373}.
CC   -!- DISRUPTION PHENOTYPE: No effect on protein secretion by the type III
CC       secretion system (TTSS) encoded in the locus of effacement (LEE).
CC       {ECO:0000269|PubMed:26727373}.
CC   -!- SIMILARITY: Belongs to the UPF0597 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01845}.
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DR   EMBL; AE005174; AAG58241.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37413.1; -; Genomic_DNA.
DR   PIR; E85972; E85972.
DR   PIR; F91127; F91127.
DR   RefSeq; NP_312017.1; NC_002695.1.
DR   RefSeq; WP_000460512.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XAF6; -.
DR   SMR; Q8XAF6; -.
DR   STRING; 155864.EDL933_4331; -.
DR   EnsemblBacteria; AAG58241; AAG58241; Z4462.
DR   EnsemblBacteria; BAB37413; BAB37413; ECs_3990.
DR   GeneID; 916164; -.
DR   KEGG; ece:Z4462; -.
DR   KEGG; ecs:ECs_3990; -.
DR   PATRIC; fig|386585.9.peg.4164; -.
DR   eggNOG; COG3681; Bacteria.
DR   HOGENOM; CLU_051840_0_0_6; -.
DR   OMA; GAMIPVM; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   HAMAP; MF_01845; UPF0597; 1.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR021144; UPF0597.
DR   PANTHER; PTHR30501; PTHR30501; 1.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   PIRSF; PIRSF006054; UCP006054; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..436
FT                   /note="UPF0597 protein YhaM"
FT                   /id="PRO_0000339821"
SQ   SEQUENCE   436 AA;  45346 MW;  C7A5E9921C4CE45C CRC64;
     MFDSTLNPLW QRYILAVQEE VKPALGCTEP ISLALAAAVA AAELEGPVER VEAWVSPNLM
     KNGLGVTVPG TGMVGLPIAA ALGALGGNAN AGLEVLKDAT AQAIADAKAL LAAGKVSVKI
     QEPCNEILFS RAKVWNGEKW ACVTIVGGHT NIVHIETHDG VVFTQQACVA EGEQESPLSV
     LSRTTLAEIL KFVNEVPFAA IRFILDSAKL NCALSQEGLS GKWGLHIGAT LEKQCERGLL
     AKDLSSSIVI RTSAASDARM GGATLPAMSN SGSGNQGITA TMPVVVVAEH FGADDERLAR
     ALMLSHLSAI YIHNQLPRLS ALCAATTAAM GAAAGMAWLV DGRYETISMA ISSMIGDVSG
     MICDGASNSC AMKVSTSASA AWKAVLMALD DTAVTGNEGI VAHDVEQSIA NLCALASHSM
     QQTDRQIIEI MASKAR