YHAO_BACSU
ID YHAO_BACSU Reviewed; 408 AA.
AC O07522; Q796V4;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized metallophosphoesterase YhaO;
GN Name=yhaO; OrderedLocusNames=BSU09910;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP INDUCTION BY MITOMYCIN C AND UV, AND PROBABLE OPERON STRUCTURE.
RC STRAIN=168 / YB886 / BG214;
RX PubMed=16267290; DOI=10.1128/jb.187.22.7655-7666.2005;
RA Au N., Kuester-Schoeck E., Mandava V., Bothwell L.E., Canny S.P.,
RA Chachu K., Colavito S.A., Fuller S.N., Groban E.S., Hensley L.A.,
RA O'Brien T.C., Shah A., Tierney J.T., Tomm L.L., O'Gara T.M., Goranov A.I.,
RA Grossman A.D., Lovett C.M.;
RT "Genetic composition of the Bacillus subtilis SOS system.";
RL J. Bacteriol. 187:7655-7666(2005).
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC Note=Binds 2 divalent metal cations. {ECO:0000250};
CC -!- INDUCTION: By mitomycin C and UV irradiation which requires RecA;
CC probably a member of the yhaONM operon. {ECO:0000269|PubMed:16267290}.
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC {ECO:0000305}.
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DR EMBL; Y14078; CAA74422.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12831.1; -; Genomic_DNA.
DR PIR; A69819; A69819.
DR RefSeq; NP_388872.1; NC_000964.3.
DR RefSeq; WP_003233258.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O07522; -.
DR SMR; O07522; -.
DR IntAct; O07522; 1.
DR STRING; 224308.BSU09910; -.
DR PaxDb; O07522; -.
DR PRIDE; O07522; -.
DR EnsemblBacteria; CAB12831; CAB12831; BSU_09910.
DR GeneID; 936282; -.
DR KEGG; bsu:BSU09910; -.
DR PATRIC; fig|224308.179.peg.1064; -.
DR eggNOG; COG0420; Bacteria.
DR InParanoid; O07522; -.
DR OMA; FVYAMKW; -.
DR PhylomeDB; O07522; -.
DR BioCyc; BSUB:BSU09910-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0004529; F:exodeoxyribonuclease activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041796; Mre11_N.
DR InterPro; IPR014576; Pesterase_YhaO.
DR Pfam; PF00149; Metallophos; 1.
DR PIRSF; PIRSF033091; Pesterase_YhaO; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Metal-binding; Reference proteome.
FT CHAIN 1..408
FT /note="Uncharacterized metallophosphoesterase YhaO"
FT /id="PRO_0000388339"
FT BINDING 35
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 61
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 61
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 96
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 408 AA; 46811 MW; 0F52BFF5B95244C9 CRC64;
MLTDLTFIHA ADLHLDSPFY GISHLPEPIF ARIKESTFAS VRHMIDAAVR EHVDFILLAG
DLFDEANRSL KAQLFLKKQF ERLRECGISV YVIFGNHDHL GGEWTPIEWP ENVHIFSSAV
PEEKSFFKEG RRIASIYGFS YQARALMENQ AARYRRSTDA PFHIGMLHGT LSGSEGHDPY
CPFTHDDLVK SGMDYWALGH IHKRQVLSAE HPAVIYPGNT QARHIKETGD KGYYLVHVTN
GDISYEFQRA HDVLWEKAAV DVTEAKNMTA LFQMVEDTFS KLRKKGSPVC VRLVLQGTAP
EWLLEAPKGT LDEFLEALQE QEAEEERFVW PLRLDDETEN EANLTNLDPF FGGLFEDIDR
SDLSDVLEGL ERHPVYRRHA DRFSQEEVKE IKEQAQIILK RQLKVLDT
