ID   YHAV_ECO57              Reviewed;         154 AA.
AC   P64595; P42901;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Toxin YhaV;
DE            EC=3.1.-.-;
DE   AltName: Full=Ribonuclease YhaV;
GN   Name=yhaV; OrderedLocusNames=Z4482, ECs4008;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Has
CC       RNase activity in vitro. Acts as a transcription factor. The YhaV/PrlF
CC       complex binds the prlF-yhaV operon, probably negatively regulating its
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer; forms a complex with PrlF (SohA) with
CC       stoichiometry PrlF(2)-YhaV(4), possibly as a YhaV(2)-PrlF(2)-YhaV(2)
CC       complex like the MazFE complex. May dimerize in solution (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; AE005174; AAG58260.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37431.1; -; Genomic_DNA.
DR   PIR; H85974; H85974.
DR   PIR; H91129; H91129.
DR   RefSeq; NP_312035.1; NC_002695.1.
DR   RefSeq; WP_000347273.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P64595; -.
DR   SMR; P64595; -.
DR   STRING; 155864.EDL933_4350; -.
DR   EnsemblBacteria; AAG58260; AAG58260; Z4482.
DR   EnsemblBacteria; BAB37431; BAB37431; ECs_4008.
DR   GeneID; 916158; -.
DR   KEGG; ece:Z4482; -.
DR   KEGG; ecs:ECs_4008; -.
DR   PATRIC; fig|386585.9.peg.4183; -.
DR   eggNOG; ENOG502ZB6Z; Bacteria.
DR   HOGENOM; CLU_137758_0_0_6; -.
DR   OMA; MQRHGWT; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0110001; C:toxin-antitoxin complex; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   InterPro; IPR021679; Toxin_endonuclease_YhaV.
DR   Pfam; PF11663; Toxin_YhaV; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Repressor;
KW   Toxin-antitoxin system; Transcription; Transcription regulation.
FT   CHAIN           1..154
FT                   /note="Toxin YhaV"
FT                   /id="PRO_0000169451"
SQ   SEQUENCE   154 AA;  17836 MW;  758EBC8263326962 CRC64;
     MDFPQRVNGW ALYAHPCFQE TYDALVAEVE TLKGKDPENY QRKAATKLLA VVHKVIEEHI
     TVNPSSPAFR HGKSLGSGKN KDWSRVKFGA GRYRLFFRYS EKEKVIILGW MNDENTLRTY
     GKKTDAYTVF SKMLKRGHPP ADWETLTRET EETH