ID   YHAV_ECOL6              Reviewed;         154 AA.
AC   Q8FDB4;
DT   09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Toxin YhaV;
DE            EC=3.1.-.-;
DE   AltName: Full=Ribonuclease YhaV;
GN   Name=yhaV; OrderedLocusNames=c3885;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=23055930; DOI=10.1371/journal.ppat.1002954;
RA   Norton J.P., Mulvey M.A.;
RT   "Toxin-antitoxin systems are important for niche-specific colonization and
RT   stress resistance of uropathogenic Escherichia coli.";
RL   PLoS Pathog. 8:E1002954-E1002954(2012).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Has
CC       RNase activity in vitro. Acts as a transcription factor. The YhaV/PrlF
CC       complex binds the prlF-yhaV operon, probably negatively regulating its
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer; forms a complex with PrlF (SohA) with
CC       stoichiometry PrlF(2)-YhaV(4), possibly as a YhaV(2)-PrlF(2)-YhaV(2)
CC       complex like the MazFE complex. May dimerize in solution (By
CC       similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the prlF-yhaV operon has no effect on
CC       virulence in mouse infection; the disrupted strain is as virulent as
CC       wild-type. {ECO:0000269|PubMed:23055930}.
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DR   EMBL; AE014075; AAN82326.1; -; Genomic_DNA.
DR   RefSeq; WP_000347252.1; NC_004431.1.
DR   AlphaFoldDB; Q8FDB4; -.
DR   SMR; Q8FDB4; -.
DR   STRING; 199310.c3885; -.
DR   EnsemblBacteria; AAN82326; AAN82326; c3885.
DR   KEGG; ecc:c3885; -.
DR   eggNOG; ENOG502ZB6Z; Bacteria.
DR   HOGENOM; CLU_137758_0_0_6; -.
DR   OMA; MQRHGWT; -.
DR   BioCyc; ECOL199310:C3885-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0110001; C:toxin-antitoxin complex; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   InterPro; IPR021679; Toxin_endonuclease_YhaV.
DR   Pfam; PF11663; Toxin_YhaV; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Repressor; Toxin-antitoxin system;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..154
FT                   /note="Toxin YhaV"
FT                   /id="PRO_0000420799"
SQ   SEQUENCE   154 AA;  17750 MW;  7590078B13276BB2 CRC64;
     MDFPQRVNGW ALYAHPCFQE TYDALVAEVE ALKGKDPENY QRKAATKLLA VVHKVIEEHI
     TVNPSSPAFR HGKSLGSGKN KDWSRVKFGA GRYRLFFRYS EKEKVIILGW MNDENTLRTY
     GKKTDAYTVF SKMLKRGHPP ADWESLTQET EESH