YHAX_BACSU
ID YHAX_BACSU Reviewed; 288 AA.
AC O07539;
DT 22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Stress response protein YhaX;
GN Name=yhaX; OrderedLocusNames=BSU09830;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=10568751; DOI=10.1101/gr.9.11.1116;
RA Medigue C., Rose M., Viari A., Danchin A.;
RT "Detecting and analyzing DNA sequencing errors: toward a higher quality of
RT the Bacillus subtilis genome sequence.";
RL Genome Res. 9:1116-1127(1999).
RN [4]
RP TRANSCRIPTIONAL REGULATION.
RX PubMed=11988534; DOI=10.1099/00221287-148-5-1593;
RA Pragai Z., Harwood C.R.;
RT "Regulatory interactions between the Pho and sigma(B)-dependent general
RT stress regulons of Bacillus subtilis.";
RL Microbiology 148:1593-1602(2002).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
RG Midwest center for structural genomics (MCSG);
RT "Crystal structure of stress response protein yhaX from Bacillus
RT subtilis.";
RL Submitted (JUL-2008) to the PDB data bank.
CC -!- INDUCTION: By phosphate starvation, via the PhoP/PhoR two-component
CC regulatory system. {ECO:0000269|PubMed:11988534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA74455.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y14080; CAA74455.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL009126; CAB12822.2; -; Genomic_DNA.
DR PIR; B69820; B69820.
DR RefSeq; NP_388864.2; NC_000964.3.
DR RefSeq; WP_003233277.1; NZ_JNCM01000035.1.
DR PDB; 3DNP; X-ray; 1.85 A; A=1-287.
DR PDBsum; 3DNP; -.
DR AlphaFoldDB; O07539; -.
DR SMR; O07539; -.
DR STRING; 224308.BSU09830; -.
DR PaxDb; O07539; -.
DR PRIDE; O07539; -.
DR DNASU; 939288; -.
DR EnsemblBacteria; CAB12822; CAB12822; BSU_09830.
DR GeneID; 939288; -.
DR KEGG; bsu:BSU09830; -.
DR PATRIC; fig|224308.179.peg.1055; -.
DR eggNOG; COG0561; Bacteria.
DR InParanoid; O07539; -.
DR OMA; MPDHRLG; -.
DR PhylomeDB; O07539; -.
DR BioCyc; BSUB:BSU09830-MON; -.
DR EvolutionaryTrace; O07539; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR000150; Cof.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR00099; Cof-subfamily; 1.
DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Stress response.
FT CHAIN 1..288
FT /note="Stress response protein YhaX"
FT /id="PRO_0000049552"
FT STRAND 5..8
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 10..14
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 23..34
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 38..42
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 47..56
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 66..68
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 70..74
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 79..81
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 86..97
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 102..106
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 121..125
FT /evidence="ECO:0007829|PDB:3DNP"
FT TURN 133..135
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 138..140
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 144..150
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 156..161
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 164..166
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 167..177
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 181..187
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 190..195
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 200..210
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 215..217
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 218..222
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 225..227
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 228..233
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 234..239
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 245..250
FT /evidence="ECO:0007829|PDB:3DNP"
FT STRAND 251..254
FT /evidence="ECO:0007829|PDB:3DNP"
FT TURN 258..261
FT /evidence="ECO:0007829|PDB:3DNP"
FT HELIX 262..276
FT /evidence="ECO:0007829|PDB:3DNP"
SQ SEQUENCE 288 AA; 32408 MW; 0A743AC6C43A0FF7 CRC64;
MSKQLLALNI DGALLRSNGK IHQATKDAIE YVKKKGIYVT LVTNRHFRSA QKIAKSLKLD
AKLITHSGAY IAEKIDAPFF EKRISDDHTF NIVQVLESYQ CNIRLLHEKY SIGNKKKVNS
NLLGKALIHP SDPIFYPVQF VESLSDLLMD EPVSAPVIEV YTEHDIQHDI TETITKAFPA
VDVIRVNDEK LNIVPKGVSK EAGLALVASE LGLSMDDVVA IGHQYDDLPM IELAGLGVAM
GNAVPEIKRK ADWVTRSNDE QGVAYMMKEY FRMQQRKGFL DKFHMKRV
