YHB7_YEAST
ID YHB7_YEAST Reviewed; 532 AA.
AC P38745; D3DKR6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Uncharacterized membrane protein YHL071W;
DE Flags: Precursor;
GN OrderedLocusNames=YHL017W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 14600 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the LU7TM family. {ECO:0000305}.
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DR EMBL; U11582; AAB65070.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06668.1; -; Genomic_DNA.
DR PIR; S46831; S46831.
DR RefSeq; NP_011846.1; NM_001179097.1.
DR AlphaFoldDB; P38745; -.
DR BioGRID; 36406; 66.
DR DIP; DIP-4577N; -.
DR IntAct; P38745; 4.
DR STRING; 4932.YHL017W; -.
DR iPTMnet; P38745; -.
DR MaxQB; P38745; -.
DR PaxDb; P38745; -.
DR PRIDE; P38745; -.
DR EnsemblFungi; YHL017W_mRNA; YHL017W; YHL017W.
DR GeneID; 856369; -.
DR KEGG; sce:YHL017W; -.
DR SGD; S000001009; YHL017W.
DR VEuPathDB; FungiDB:YHL017W; -.
DR eggNOG; KOG2568; Eukaryota.
DR GeneTree; ENSGT00940000169607; -.
DR HOGENOM; CLU_024065_1_0_1; -.
DR InParanoid; P38745; -.
DR OMA; DMEHSTG; -.
DR BioCyc; YEAST:G3O-31037-MON; -.
DR PRO; PR:P38745; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38745; protein.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR InterPro; IPR009637; GPR107/GPR108-like.
DR PANTHER; PTHR21229; PTHR21229; 1.
DR Pfam; PF06814; Lung_7-TM_R; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..532
FT /note="Uncharacterized membrane protein YHL071W"
FT /id="PRO_0000014326"
FT TOPO_DOM 21..193
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..262
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..330
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 397..414
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..532
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 497
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 532 AA; 61206 MW; EF2CB7CB74006503 CRC64;
MDRTWLLLTW LLLLCGVVQG NQESINQKYH DVCSGMYSKE DFNGKVDPYI SFTLEELSLA
DEDDDGEGVS VAVFDFQDYE HIGVRLPNGE IQYICDDYAL DLGLCEDSSE GQFIIQETAI
DPFTSKEHKL TSQILTFTQQ ELGTNDKVYS INKTGYYCVT TSSFISSSSK FKATVNFRNA
YGQLDASEAY KMPIYAFLAV AYAVCTLVYS WLCWKHRHEL LPLQRYILVF CIFLTADTIF
VWMYYIIENQ KGNSSVALHV YMVFISIFSA GKMTFTLLLA LLISLGYGIV YPKLDRTLLR
RCQIFAIFTF AVCVAFLVQK YSQNSESLSN LILITAIPLV LCLFAFYYLT LSSMNKTMTY
LREQNQVVKL NMYRKLIILC YISLFILFLG LLVSTFAYVG MDTVDMIEQY WKTEFLITDT
WPSFVYFLVF VIFAFFWRPT STSYLLACSH QLPTDMENVS EFDLDDINSL SDEALPNREP
RNDYQEHDHN MDIDLASDFE EVPSVNANTN ANNDVLFDVD YDRDAKNDRS TT
