YHBX_ECO57
ID YHBX_ECO57 Reviewed; 541 AA.
AC P58216;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Putative transferase YhbX;
DE EC=2.-.-.-;
GN Name=yhbX; OrderedLocusNames=Z4535, ECs4053;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=O157:H7 / EHEC;
RA Zhao S., Mitchell S.E., Meng J., Doyle M.P., Kresovich S.;
RT "Cloning and sequencing a gene associated with an outer membrane protein of
RT Escherichia coli O157:H7.";
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [4]
RP OVEREXPRESSION.
RX PubMed=16514146; DOI=10.1099/mic.0.28692-0;
RA Kim S.H., Jia W., Parreira V.R., Bishop R.E., Gyles C.L.;
RT "Phosphoethanolamine substitution in the lipid A of Escherichia coli
RT O157:H7 and its association with PmrC.";
RL Microbiology 152:657-666(2006).
CC -!- FUNCTION: There are several lipid A forms in this strain, including a
CC phosphoethanolamine (1-O-P-pEtN) form; overexpression of this gene does
CC not lead to higher levels of the 1-O-P-pEtN form of lipid A.
CC {ECO:0000269|PubMed:16514146}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P42640}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the phosphoethanolamine transferase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA96312.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAG58308.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB37476.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U50906; AAA96312.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE005174; AAG58308.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB37476.1; ALT_INIT; Genomic_DNA.
DR PIR; E91135; E91135.
DR PIR; H85980; H85980.
DR RefSeq; NP_312080.2; NC_002695.1.
DR RefSeq; WP_001310166.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P58216; -.
DR SMR; P58216; -.
DR STRING; 155864.EDL933_4402; -.
DR EnsemblBacteria; AAG58308; AAG58308; Z4535.
DR EnsemblBacteria; BAB37476; BAB37476; ECs_4053.
DR GeneID; 916107; -.
DR KEGG; ece:Z4535; -.
DR KEGG; ecs:ECs_4053; -.
DR PATRIC; fig|386585.9.peg.4232; -.
DR eggNOG; COG2194; Bacteria.
DR HOGENOM; CLU_039390_4_1_6; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR Gene3D; 3.40.720.10; -; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR040423; PEA_transferase.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR30443; PTHR30443; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; SSF53649; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..541
FT /note="Putative transferase YhbX"
FT /id="PRO_0000209147"
FT TOPO_DOM 1..60
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..110
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..141
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..541
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 541 AA; 60639 MW; B9C140B660FA0E89 CRC64;
MTVFNKFARS FKSHWLLYLS VIVFGITNLV ASSGAHMVQR LLFFVLTILV VKRISSLPLR
LLVAAPFVLL TAADMSISLY SWCTFGTTFN DGFAISVLQS DPDEVAKMLG MYSPYLCAFA
FLSLLFLAVI IKYDVSLPTK KVTGILLLIV ISGSLFSACQ FAYKDAKNKN AFSPYILASR
FATYTPFFNL NYFALAAKEH QRLLSIANTV PYFQLSVRDT GIDTYVLIVG ESVRVDNMSL
YGYTRSTTPQ VEAQRKQIKL FNQAISGAPY TALSVPLSLT ADSVLSHDIH NYPDNIINMA
NQAGFQTFWL SSQSAFRQNG TAVTSIAMRA METVYVRGFD ELLLPHLSQA LQQNTQQKKL
IVLHLNGSHE PACSAYPQSS AVFQPQDDQD ACYDNSIHYT DSLLGQVFEL LKDRRASVMY
FADHGLERDP TKKNVYFHGG REASQQAYHV PMFIWYSPVL GDGVDRTTEN NIFSTAYNNY
LINAWMGVTK PEQPQTLEEV IVHYKGDSLV VDANHDVFDY VMLRKEFTED KQGNPTPEGQ
G
