ID   YHC3_SCHPO              Reviewed;         649 AA.
AC   O60167;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=ENTH domain-containing protein C19F8.03c;
GN   ORFNames=SPBC19F8.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-287; THR-414 AND
RP   SER-417, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329671; CAA19123.1; -; Genomic_DNA.
DR   PIR; T39826; T39826.
DR   RefSeq; NP_596345.1; NM_001022265.2.
DR   AlphaFoldDB; O60167; -.
DR   SMR; O60167; -.
DR   BioGRID; 277226; 11.
DR   STRING; 4896.SPBC19F8.03c.1; -.
DR   iPTMnet; O60167; -.
DR   MaxQB; O60167; -.
DR   PaxDb; O60167; -.
DR   PRIDE; O60167; -.
DR   EnsemblFungi; SPBC19F8.03c.1; SPBC19F8.03c.1:pep; SPBC19F8.03c.
DR   GeneID; 2540702; -.
DR   KEGG; spo:SPBC19F8.03c; -.
DR   PomBase; SPBC19F8.03c; -.
DR   VEuPathDB; FungiDB:SPBC19F8.03c; -.
DR   eggNOG; KOG0251; Eukaryota.
DR   HOGENOM; CLU_014248_2_0_1; -.
DR   InParanoid; O60167; -.
DR   Reactome; R-SPO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:O60167; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0030479; C:actin cortical patch; ISO:PomBase.
DR   GO; GO:0005905; C:clathrin-coated pit; IBA:GO_Central.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0032050; F:clathrin heavy chain binding; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISM:PomBase.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; ISO:PomBase.
DR   GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   Gene3D; 1.20.58.150; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; PTHR22951; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; SSF48464; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..649
FT                   /note="ENTH domain-containing protein C19F8.03c"
FT                   /id="PRO_0000303952"
FT   DOMAIN          2..136
FT                   /note="ENTH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00243"
FT   REGION          280..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          409..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          590..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..377
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         285
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         287
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         414
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         417
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   649 AA;  72985 MW;  25990078ACF20CC6 CRC64;
     MSPSKWLLTY ERAVKKATKV KLAAPKYKHV EIILEATTED PETLENVIQA LCERLKEQSW
     TIVFKTLIVF HVMLKEGAPN TTIVALSQRP RILEVLKASS LLAQGKNIYN YSRFLSERAK
     QYGRLGVDYA QVGDAPKKKI REMKLENGLL RNVEGIQAQL RRLIKCQFVA EEIDNDIAIT
     AFRLLVGDLL VLFKAVNIGV INVLEHYFEM GHHDAAQSLR IYKTFVNQTE DIINYLSTAR
     SLEFVTKFPV PNIKHAPISL TASLEEYLND PDFEENRKQY LQNKSGSPVE ETAILNRKPT
     LRKKKSIPKK QNESSSTIQK ENTVQQEASS SEEEAVKSLP ETQRTTSRIE TQEEEIKEEE
     MEGEEEEEEE EVPNYESENE LEDKVGDLSL SLGVASSFVD EMLRERNNLS AEGTSASPSL
     DKKSESTNIV QPIPSHPNDS LNPFYNSSSP TYHPQPIPPQ LQQVQLLSQM AGNQMANIQY
     TMNGMQQTGA SPNTALNISQ VNMYAQNNPV NPSTTNPFQN FLRQPSYQGM QFEQQQPTTI
     PLQPNIPVLN QQYPVMIPAM EDSRGPLPSP AHIMYPEGSP GFIQHSPNGF THGHSASPVN
     IGQKLDVPER PMSTPYTASK NPFSTRELAE PTDLARNSIS TESKNPFRS