ID   YHCA_ECOLI              Reviewed;         224 AA.
AC   P28722; Q2M8Z7;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Uncharacterized fimbrial chaperone YhcA;
DE   Flags: Precursor;
GN   Name=yhcA; OrderedLocusNames=b3215, JW3182;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=1447980; DOI=10.1111/j.1365-2958.1992.tb01450.x;
RA   Castano I., Flores N., Valle F., Covarrubias A.A., Bolivar F.;
RT   "gltF, a member of the gltBDF operon of Escherichia coli, is involved in
RT   nitrogen-regulated gene expression.";
RL   Mol. Microbiol. 6:2733-2741(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Could be required for the biogenesis of a putative fimbria.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the periplasmic pilus chaperone family.
CC       {ECO:0000305}.
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DR   EMBL; M74162; AAA23910.1; -; Genomic_DNA.
DR   EMBL; U18997; AAA58017.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76247.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77259.1; -; Genomic_DNA.
DR   PIR; A65113; A65113.
DR   RefSeq; NP_417682.1; NC_000913.3.
DR   RefSeq; WP_001311157.1; NZ_SSZK01000007.1.
DR   AlphaFoldDB; P28722; -.
DR   SMR; P28722; -.
DR   BioGRID; 4259287; 6.
DR   BioGRID; 852053; 3.
DR   IntAct; P28722; 14.
DR   STRING; 511145.b3215; -.
DR   PaxDb; P28722; -.
DR   PRIDE; P28722; -.
DR   EnsemblBacteria; AAC76247; AAC76247; b3215.
DR   EnsemblBacteria; BAE77259; BAE77259; BAE77259.
DR   GeneID; 947741; -.
DR   KEGG; ecj:JW3182; -.
DR   KEGG; eco:b3215; -.
DR   PATRIC; fig|1411691.4.peg.3514; -.
DR   EchoBASE; EB1477; -.
DR   eggNOG; COG3121; Bacteria.
DR   HOGENOM; CLU_070768_1_2_6; -.
DR   OMA; LPHAWIL; -.
DR   PhylomeDB; P28722; -.
DR   BioCyc; EcoCyc:EG11515-MON; -.
DR   PRO; PR:P28722; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0071555; P:cell wall organization; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008962; PapD-like_sf.
DR   InterPro; IPR036316; Pili_assmbl_chap_C_dom_sf.
DR   InterPro; IPR016147; Pili_assmbl_chaperone_N.
DR   Pfam; PF00345; PapD_N; 1.
DR   SUPFAM; SSF49354; SSF49354; 1.
DR   SUPFAM; SSF49584; SSF49584; 1.
PE   3: Inferred from homology;
KW   Chaperone; Fimbrium biogenesis; Immunoglobulin domain; Periplasm;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..224
FT                   /note="Uncharacterized fimbrial chaperone YhcA"
FT                   /id="PRO_0000009295"
FT   CONFLICT        24..58
FT                   /note="PETSVLLVDEKRGEASINIKNTDDHPSLLYTTIVD -> LKHQYCWLMKSVV
FT                   KLVLILRIQMIILHCFTPPLLI (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        204..224
FT                   /note="VEFYPASRYGYRGNKYVTDLK -> GRVLPSQPIWLSR (in Ref. 1;
FT                   AAA23910)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   224 AA;  25339 MW;  CFD7E170E7C99684 CRC64;
     MLRHITFTVF ITTSMNTLAT GMVPETSVLL VDEKRGEASI NIKNTDDHPS LLYTTIVDLP
     ESNKSIRLIP TQPVIRVEAG QVQQVRFLLQ ATVPLQSEEL KRVTFEGIPP KDDKSSRVTV
     SIRQDLPVLI HPASLPEERE TWKFLEWRKN GDQIEISNPS NYVVRMTLQF KTLPSGKTGA
     INKTYFLPHT STTTALTNAT DTKVEFYPAS RYGYRGNKYV TDLK