ID   YHCC_ECO57              Reviewed;         309 AA.
AC   P0ADW7; P45476;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Uncharacterized protein YhcC {ECO:0000305};
GN   Name=yhcC; OrderedLocusNames=Z4575, ECs4090;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250|UniProtKB:Q9X0Z6};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000250|UniProtKB:Q9X0Z6};
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58345.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37513.1; -; Genomic_DNA.
DR   PIR; B91140; B91140.
DR   PIR; E85985; E85985.
DR   RefSeq; NP_312117.1; NC_002695.1.
DR   RefSeq; WP_001299745.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ADW7; -.
DR   SMR; P0ADW7; -.
DR   STRING; 155864.EDL933_4439; -.
DR   EnsemblBacteria; AAG58345; AAG58345; Z4575.
DR   EnsemblBacteria; BAB37513; BAB37513; ECs_4090.
DR   GeneID; 916061; -.
DR   KEGG; ece:Z4575; -.
DR   KEGG; ecs:ECs_4090; -.
DR   PATRIC; fig|386585.9.peg.4269; -.
DR   eggNOG; COG1242; Bacteria.
DR   HOGENOM; CLU_060920_0_0_6; -.
DR   OMA; NAGFTCP; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.30.20; -; 1.
DR   InterPro; IPR039661; ELP3.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR032432; Radical_SAM_C.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR005911; YhcC-like.
DR   PANTHER; PTHR11135; PTHR11135; 1.
DR   PANTHER; PTHR11135:SF1; PTHR11135:SF1; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF16199; Radical_SAM_C; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01091; uncharacterized_CHP01210-like; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR01212; TIGR01212; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..309
FT                   /note="Uncharacterized protein YhcC"
FT                   /id="PRO_0000169482"
FT   DOMAIN          17..254
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   BINDING         33
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X0Z6"
FT   BINDING         45
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X0Z6"
FT   BINDING         48
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X0Z6"
SQ   SEQUENCE   309 AA;  34607 MW;  61B3187BB77CA1A9 CRC64;
     MQLQKLVNMF GGDLTRRYGQ KVHKLTLHGG FSCPNRDGTI GRGGCTFCNV ASFADEAQQH
     RSIAEQLAHQ ANLVNRAKRY LAYFQAYTST FAEVQVLRSM YQQAVSQANI VGLCVGTRPD
     CVPDAVLDLL CEYKDQGYEV WLELGLQTAH DKTLHRINRG HDFACYQRTT QLARQRGLKV
     CSHLIVGLPG EGQAECLQTL ERVVETGVDG IKLHPLHIVK GSIMAKAWEA GRLNGIELED
     YTLTAGEMIR HTPPEVIYHR ISASARRPTL LAPLWCENRW TGMVELDRYL NEHGVQGSAL
     GRPWLPPTE