ID   YHDI_BACSU              Reviewed;         469 AA.
AC   O07578; Q796X5;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator YhdI;
GN   Name=yhdI; OrderedLocusNames=BSU09480;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA   Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA   Venema G., Bron S.;
RT   "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT   subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT   many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL   Microbiology 144:859-875(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=12123465; DOI=10.1046/j.1365-2958.2002.03036.x;
RA   Belitsky B.R., Sonenshein A.L.;
RT   "GabR, a member of a novel protein family, regulates the utilization of
RT   gamma-aminobutyrate in Bacillus subtilis.";
RL   Mol. Microbiol. 45:569-583(2002).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC       pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
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DR   EMBL; Y14082; CAA74493.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12787.1; -; Genomic_DNA.
DR   PIR; G69825; G69825.
DR   RefSeq; NP_388829.1; NC_000964.3.
DR   RefSeq; WP_003245209.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O07578; -.
DR   SMR; O07578; -.
DR   STRING; 224308.BSU09480; -.
DR   PaxDb; O07578; -.
DR   PRIDE; O07578; -.
DR   EnsemblBacteria; CAB12787; CAB12787; BSU_09480.
DR   GeneID; 939277; -.
DR   KEGG; bsu:BSU09480; -.
DR   PATRIC; fig|224308.179.peg.1021; -.
DR   eggNOG; COG1167; Bacteria.
DR   InParanoid; O07578; -.
DR   OMA; RIGFMVM; -.
DR   PhylomeDB; O07578; -.
DR   BioCyc; BSUB:BSU09480-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   Pfam; PF00392; GntR; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; DNA-binding; Pyridoxal phosphate; Reference proteome;
KW   Transcription; Transcription regulation; Transferase.
FT   CHAIN           1..469
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   YhdI"
FT                   /id="PRO_0000360698"
FT   DOMAIN          13..81
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        41..60
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   MOD_RES         309
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   469 AA;  52764 MW;  0B31E425069B19F1 CRC64;
     MDITPFLDKK SKTPLYEQLY TFFKQEISHA RITKGTRLPS KRRLSSLLDV STATIERAYE
     QLTAEGYVKS KPKIGWFAAE VEPGFPTAPD HFQQSVQPGL HQKNAPAIDF HQGSVDPTLF
     PFNAWRKSIV KSLDRYSGSF HTSGDPQGEY ELRHMIARFV RLSRGVNCEP GQIIIGAGTT
     VLLQNLCLSL KPGTKIGFEE PGFHRSRRMF EANHMDVTPI CSDAEGVLPD ELYRQNPYLM
     YTTPSHQFPI GTIMTITRRQ ELLAWAAETN SFIIEDDYDG EFRYSGHPIP SLQGLDPNGR
     VIYLGTFSKS LLPSLRLSFM IVPPELMEPI QNNVQLMKQT VSAHSQLALA DFIETGEWQK
     HINRMRSLYR KKHAVLLEAI RSELGNTVEI LGKNSGLHIL LRLLFPASEE EAIQAAADHG
     VTLYPVSPSY IEQTPFTSVL IGYGGLSEED IRLGIQKLKT AWAPLISSY