YHDK_BACSU
ID YHDK_BACSU Reviewed; 96 AA.
AC O07580;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable anti-sigma-M factor YhdK;
GN Name=yhdK; OrderedLocusNames=BSU09500;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP TRANSCRIPTION.
RC STRAIN=168;
RX PubMed=10216858; DOI=10.1046/j.1365-2958.1999.01323.x;
RA Horsburgh M.J., Moir A.;
RT "Sigma M, an ECF RNA polymerase sigma factor of Bacillus subtilis 168, is
RT essential for growth and survival in high concentrations of salt.";
RL Mol. Microbiol. 32:41-50(1999).
RN [4]
RP INTERACTION OF YHDL WITH YHDK.
RX PubMed=14993308; DOI=10.1099/mic.0.26712-0;
RA Yoshimura M., Asai K., Sadaie Y., Yoshikawa H.;
RT "Interaction of Bacillus subtilis extracytoplasmic function (ECF) sigma
RT factors with the N-terminal regions of their potential anti-sigma
RT factors.";
RL Microbiology 150:591-599(2004).
CC -!- SUBUNIT: Interacts specifically with YhdL, while the N-terminus of YhdL
CC interacts with sigma-M. {ECO:0000269|PubMed:14993308}.
CC -!- INTERACTION:
CC O07580; O07581: yhdL; NbExp=4; IntAct=EBI-2122277, EBI-2122262;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Cotranscribed with sigma-M and yhdL. YhdK and YhdL
CC negatively regulate sigma-M.
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DR EMBL; Y14082; CAA74495.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12789.1; -; Genomic_DNA.
DR PIR; A69826; A69826.
DR RefSeq; NP_388831.1; NC_000964.3.
DR RefSeq; WP_003233341.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O07580; -.
DR SMR; O07580; -.
DR IntAct; O07580; 1.
DR STRING; 224308.BSU09500; -.
DR PaxDb; O07580; -.
DR EnsemblBacteria; CAB12789; CAB12789; BSU_09500.
DR GeneID; 936268; -.
DR KEGG; bsu:BSU09500; -.
DR PATRIC; fig|224308.179.peg.1023; -.
DR eggNOG; ENOG5030CR2; Bacteria.
DR OMA; WTIVSID; -.
DR BioCyc; BSUB:BSU09500-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR020496; YhdK.
DR Pfam; PF17453; Sigma_M_inh; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..96
FT /note="Probable anti-sigma-M factor YhdK"
FT /id="PRO_0000049569"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 96 AA; 10642 MW; AAA1BCD2D1F22BE8 CRC64;
MELVRIFKEH NVFGWISVGT AVLSLLLLNL AIISNVTFYS YQMLPFAMAA VPFGVVELFI
KRGRTGPGLL GVILNLFVII CVYTIVSVDT NLQFGF
