ID   YHDL_BACSU              Reviewed;         358 AA.
AC   O07581; Q796X3;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable anti-sigma-M factor YhdL;
GN   Name=yhdL; OrderedLocusNames=BSU09510;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA   Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA   Venema G., Bron S.;
RT   "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT   subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT   many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL   Microbiology 144:859-875(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   TRANSCRIPTION.
RC   STRAIN=168;
RX   PubMed=10216858; DOI=10.1046/j.1365-2958.1999.01323.x;
RA   Horsburgh M.J., Moir A.;
RT   "Sigma M, an ECF RNA polymerase sigma factor of Bacillus subtilis 168, is
RT   essential for growth and survival in high concentrations of salt.";
RL   Mol. Microbiol. 32:41-50(1999).
RN   [4]
RP   INTERACTION WITH SIGM AND YHDK.
RX   PubMed=14993308; DOI=10.1099/mic.0.26712-0;
RA   Yoshimura M., Asai K., Sadaie Y., Yoshikawa H.;
RT   "Interaction of Bacillus subtilis extracytoplasmic function (ECF) sigma
RT   factors with the N-terminal regions of their potential anti-sigma
RT   factors.";
RL   Microbiology 150:591-599(2004).
CC   -!- SUBUNIT: The N-terminus of YhdL interacts with sigma-M. YhdL interacts
CC       specifically with YhdK. {ECO:0000269|PubMed:14993308}.
CC   -!- INTERACTION:
CC       O07581; O07580: yhdK; NbExp=4; IntAct=EBI-2122262, EBI-2122277;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Cotranscribed with sigma-M and yhdK. YhdL and yhdK
CC       negatively regulate sigma-M.
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DR   EMBL; Y14082; CAA74496.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12790.1; -; Genomic_DNA.
DR   PIR; B69826; B69826.
DR   RefSeq; NP_388832.1; NC_000964.3.
DR   RefSeq; WP_010886459.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O07581; -.
DR   SMR; O07581; -.
DR   IntAct; O07581; 2.
DR   STRING; 224308.BSU09510; -.
DR   PaxDb; O07581; -.
DR   PRIDE; O07581; -.
DR   EnsemblBacteria; CAB12790; CAB12790; BSU_09510.
DR   GeneID; 939753; -.
DR   KEGG; bsu:BSU09510; -.
DR   PATRIC; fig|224308.43.peg.993; -.
DR   eggNOG; ENOG502Z96W; Bacteria.
DR   OMA; EVWNWFD; -.
DR   BioCyc; BSUB:BSU09510-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025672; Sigma_reg_C_dom.
DR   InterPro; IPR029101; Sigma_reg_N.
DR   Pfam; PF13791; Sigma_reg_C; 1.
DR   Pfam; PF13800; Sigma_reg_N; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="Probable anti-sigma-M factor YhdL"
FT                   /id="PRO_0000049570"
FT   TRANSMEM        74..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   358 AA;  40581 MW;  E084E828A33B83FD CRC64;
     MMNEEFKKRF DQYKNGEMSD QEMTAFEEEL EKLEVYQELI DSELEDDNDW DLSISPEKQK
     AILAYGKRKS YLRISVLAVI STLMILPLCT LGSYLYYGMG GKHSTGNEFM ETAAVTVALT
     MPNVLVDTSG LKSQVKLFGM NTEFPLQKQI GTKTAAVGNE RVEMFYNKVK APAVNYYDLE
     VNKTGHYFTH PSNKSEQTTA KAEKTLSTLP EGTVSEVYLS YDRAYPTKDV YNKFKGYDVS
     FLWNAIETEK NTNKTASTEP LGYPGKDSKF LAALNTKGKS NGDQFINALK FMSKHEKWAQ
     VISKRKDLNV DNRLDYVEKN GVNVYGSVVT GPTKEIQRML KNKSVKSANV GEVELWNW