YHDY_ECOLI
ID YHDY_ECOLI Reviewed; 367 AA.
AC P45768; Q2M8U5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Inner membrane amino-acid ABC transporter permease protein YhdY;
GN Name=yhdY; OrderedLocusNames=b3270, JW5545;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Probably part of the binding-protein-dependent transport
CC system YdhWXYZ for an amino acid; probably responsible for the
CC translocation of the substrate across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. HisMQ subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA58074.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U18997; AAA58074.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76302.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77311.1; -; Genomic_DNA.
DR PIR; H65119; H65119.
DR RefSeq; NP_417736.2; NC_000913.3.
DR RefSeq; WP_001300681.1; NZ_SSZK01000072.1.
DR AlphaFoldDB; P45768; -.
DR SMR; P45768; -.
DR BioGRID; 4261009; 8.
DR BioGRID; 852076; 2.
DR ComplexPortal; CPX-4450; Putative amino acid ABC transporter complex.
DR DIP; DIP-12306N; -.
DR IntAct; P45768; 3.
DR STRING; 511145.b3270; -.
DR TCDB; 3.A.1.3.26; the atp-binding cassette (abc) superfamily.
DR PaxDb; P45768; -.
DR PRIDE; P45768; -.
DR EnsemblBacteria; AAC76302; AAC76302; b3270.
DR EnsemblBacteria; BAE77311; BAE77311; BAE77311.
DR GeneID; 947764; -.
DR KEGG; ecj:JW5545; -.
DR KEGG; eco:b3270; -.
DR PATRIC; fig|511145.12.peg.3370; -.
DR EchoBASE; EB2685; -.
DR eggNOG; COG0765; Bacteria.
DR HOGENOM; CLU_019602_16_1_6; -.
DR InParanoid; P45768; -.
DR OMA; LVFWVFC; -.
DR PhylomeDB; P45768; -.
DR BioCyc; EcoCyc:YHDY-MON; -.
DR PRO; PR:P45768; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0015833; P:peptide transport; IC:ComplexPortal.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR010065; AA_ABC_transptr_permease_3TM.
DR InterPro; IPR043429; ArtM/GltK/GlnP/TcyL/YhdX-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30614; PTHR30614; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR01726; HEQRo_perm_3TM; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..367
FT /note="Inner membrane amino-acid ABC transporter permease
FT protein YhdY"
FT /id="PRO_0000060254"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 58..99
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 121..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 147..162
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 184..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 214..233
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 255..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 313..326
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 348..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 159..353
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 367 AA; 41484 MW; EC95E04BBC7418D1 CRC64;
MTKVLLSHPP RPASHNSSRA MVWVRKNLFS SWSNSLLTIG CIWLMWELIP PLLNWAFLQA
NWVGSTRADC TKAGACWVFI HERFGQFMYG LYPHDQRWRI NLALLIGLVS IAPMFWKILP
HRGRYIAAWA VIYPLIVWWL MYGGFFALER VETRQWGGLT LTLIIASVGI AGALPWGILL
ALGRRSHMPI VRILSVIFIE FWRGVPLITV LFMSSVMLPL FMAEGTSIDK LIRALVGVIL
FQSAYVAEVV RGGLQALPKG QYEAAESLAL GYWKTQGLVI LPQALKLVIP GLVNTIIALF
KDTSLVIIIG LFDLFSSVQQ ATVDPAWLGM STEGYVFAAL IYWIFCFSMS RYSQYLEKRF
NTGRTPH
