ID   YHEJ_SCHPO              Reviewed;         344 AA.
AC   P0CU15; Q9P3V8; Q9P7U6;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Uncharacterized membrane protein SPBPB2B2.19c;
GN   ORFNames=SPBPB2B2.19c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:P0CU14}. Membrane; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0742 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAC21421.1; -; Genomic_DNA.
DR   PIR; T50274; T50274.
DR   RefSeq; NP_592764.1; NM_001020927.2.
DR   RefSeq; NP_596865.1; NM_001023888.2.
DR   AlphaFoldDB; P0CU15; -.
DR   EnsemblFungi; SPBC1348.02.1; SPBC1348.02.1:pep; SPBC1348.02.
DR   EnsemblFungi; SPBPB2B2.19c.1; SPBPB2B2.19c.1:pep; SPBPB2B2.19c.
DR   GeneID; 2541343; -.
DR   GeneID; 2541576; -.
DR   KEGG; spo:SPBC1348.02; -.
DR   KEGG; spo:SPBPB2B2.19c; -.
DR   PomBase; SPBPB2B2.19c; -.
DR   VEuPathDB; FungiDB:SPBC1348.02; -.
DR   VEuPathDB; FungiDB:SPBPB2B2.19c; -.
DR   OMA; LEIWINN; -.
DR   PRO; PR:P0CU15; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018291; 5TM-prot_SCHPO.
DR   Pfam; PF09437; Pombe_5TM; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..344
FT                   /note="Uncharacterized membrane protein SPBPB2B2.19c"
FT                   /id="PRO_0000437234"
FT   TOPO_DOM        1..98
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..198
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..222
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..344
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   344 AA;  40151 MW;  CED0B251EC3A572B CRC64;
     MIDFVKSRDT VIQKSFFEEF NSQNREMGSF AYSGNSESVW TGENITSIWK TILINETGSY
     CVAARPMTMD GAEFNLDLMG YSVSEDQINN DEIGIWNYIS VAEMGGVLLF LSYWIWTCLH
     FSKIIFPAQK VICLYIFLFA LNQTLQECIE EYVFSSECIK YRQFYSVYEI IDFLRTNFYR
     LFVIYCALGF GITRTVPKYL MIKGISIVIA LCSVYWISLY KDVYVVSEIF DMIQYEVSPA
     IWVYSICHLL KQCTSVTTYE NASKARFFRR MLNAFIFIFC ASPMLHYLSN IIFGNFDYRL
     SVIIGDLFTF MEKIAFPCYI MFPTHNEALA YNRNVAEEAQ EKMI