CBIC_SALTY
ID CBIC_SALTY Reviewed; 210 AA.
AC Q05601;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cobalt-precorrin-8 methylmutase;
DE EC=5.4.99.60;
DE AltName: Full=Cobalt-precorrin isomerase;
GN Name=cbiC; OrderedLocusNames=STM2033;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC STRAIN=LT2;
RX PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT Salmonella typhimurium.";
RL J. Bacteriol. 175:3303-3316(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP PROTEIN SEQUENCE OF 1-11.
RX PubMed=1451790; DOI=10.1016/0014-5793(92)80213-z;
RA Roessner C.A., Warren M.J., Santander P.J., Atshaves B.P., Ozaki S.,
RA Stolowich N.J., Iida K., Scott A.I.;
RT "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis.
RT Identification of the 11-methyl and 20-methyl transferases of corrin
RT biosynthesis.";
RL FEBS Lett. 301:73-78(1992).
CC -!- FUNCTION: Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Co-precorrin-8X = cob(II)yrinate; Xref=Rhea:RHEA:16209,
CC ChEBI:CHEBI:58894, ChEBI:CHEBI:70792; EC=5.4.99.60;
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC step 9/10.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CobH/CbiC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L12006; AAA27254.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20937.1; -; Genomic_DNA.
DR PIR; S21127; S21127.
DR RefSeq; NP_460978.1; NC_003197.2.
DR RefSeq; WP_000558988.1; NC_003197.2.
DR AlphaFoldDB; Q05601; -.
DR SMR; Q05601; -.
DR STRING; 99287.STM2033; -.
DR PaxDb; Q05601; -.
DR EnsemblBacteria; AAL20937; AAL20937; STM2033.
DR GeneID; 1253554; -.
DR KEGG; stm:STM2033; -.
DR PATRIC; fig|99287.12.peg.2155; -.
DR HOGENOM; CLU_084703_1_1_6; -.
DR OMA; DLAWQAY; -.
DR PhylomeDB; Q05601; -.
DR BioCyc; MetaCyc:MON-13227; -.
DR BioCyc; SENT99287:STM2033-MON; -.
DR UniPathway; UPA00148; UER00230.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0043778; F:cobalt-precorrin-8 methylmutase activity; IEA:UniProtKB-EC.
DR GO; GO:0016993; F:precorrin-8X methylmutase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10230; -; 1.
DR InterPro; IPR003722; Cbl_synth_CobH/CbiC.
DR InterPro; IPR036588; CobH/CbiC_sf.
DR Pfam; PF02570; CbiC; 1.
DR SUPFAM; SSF63965; SSF63965; 1.
PE 1: Evidence at protein level;
KW Cobalamin biosynthesis; Direct protein sequencing; Isomerase;
KW Reference proteome.
FT CHAIN 1..210
FT /note="Cobalt-precorrin-8 methylmutase"
FT /id="PRO_0000135923"
FT ACT_SITE 45
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000250"
FT BINDING 14
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 42
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 210 AA; 23034 MW; C2098D0EB84BDDA5 CRC64;
MHYIQQPQTI EANSFTIISD IIRETRPDYR FASPLHEAII KRVIHTTADF DWLDILWFSA
DALEQLCDAL RHPCIIYTDT TMALSGINKR LLATFGGECR CYISDPRVVR AAQTQGITRS
MAAVDIAIAE EEKNKLFVFG NAPTALFRLL EHNVTVSGVV GVPVGFVGAA ESKEALTHSH
FPAVAALGRK GGSNVAAAIV NALLYHLREA