ID   CBIC_SYNY3              Reviewed;         217 AA.
AC   P74304;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Cobalt-precorrin-8 methylmutase;
DE            EC=5.4.99.60;
DE   AltName: Full=Cobalt-precorrin isomerase;
GN   Name=cbiC; Synonyms=cobH; OrderedLocusNames=sll0916;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-8X = cob(II)yrinate; Xref=Rhea:RHEA:16209,
CC         ChEBI:CHEBI:58894, ChEBI:CHEBI:70792; EC=5.4.99.60;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 9/10.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CobH/CbiC family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA18398.1; -; Genomic_DNA.
DR   PIR; S76139; S76139.
DR   AlphaFoldDB; P74304; -.
DR   SMR; P74304; -.
DR   STRING; 1148.1653485; -.
DR   PaxDb; P74304; -.
DR   EnsemblBacteria; BAA18398; BAA18398; BAA18398.
DR   KEGG; syn:sll0916; -.
DR   eggNOG; COG2082; Bacteria.
DR   InParanoid; P74304; -.
DR   OMA; GAPIFCD; -.
DR   PhylomeDB; P74304; -.
DR   UniPathway; UPA00148; UER00230.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0043778; F:cobalt-precorrin-8 methylmutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016993; F:precorrin-8X methylmutase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.10230; -; 1.
DR   InterPro; IPR003722; Cbl_synth_CobH/CbiC.
DR   InterPro; IPR036588; CobH/CbiC_sf.
DR   Pfam; PF02570; CbiC; 1.
DR   SUPFAM; SSF63965; SSF63965; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Isomerase; Reference proteome.
FT   CHAIN           1..217
FT                   /note="Cobalt-precorrin-8 methylmutase"
FT                   /id="PRO_0000135927"
FT   ACT_SITE        38
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         12
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         35
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  23363 MW;  C0E5107064935B5C CRC64;
     MIPLEHPILL ESFAHIDRSV GPHNLSSQEY AIARRVIHST ADFDFLHLLR FAPDLPQAEF
     DPDLPEHQAI ARGIESLRHG QTIVVDVNMV KQGIQGLVQR TFNNPIQTAI DFATIADPGK
     TRTETGMDRC IAQFPEAIYV IGNAPTALLT LCQAIAAGKA KPALVIGVPV GFIGVLEAKK
     ALSLLPCPQI RVEGNKGGSP VAAGIVNALL MLAWREG