ID   YHFK_ECOLI              Reviewed;         700 AA.
AC   P45537; Q2M724;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Uncharacterized protein YhfK;
GN   Name=yhfK; OrderedLocusNames=b3358, JW5701;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the YccS/YhfK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA58155.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U18997; AAA58155.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76383.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77932.1; -; Genomic_DNA.
DR   RefSeq; NP_417817.2; NC_000913.3.
DR   AlphaFoldDB; P45537; -.
DR   SMR; P45537; -.
DR   BioGRID; 4262927; 168.
DR   STRING; 511145.b3358; -.
DR   TCDB; 2.A.85.1.3; the aromatic acid exporter (arae) family.
DR   jPOST; P45537; -.
DR   PaxDb; P45537; -.
DR   PRIDE; P45537; -.
DR   EnsemblBacteria; AAC76383; AAC76383; b3358.
DR   EnsemblBacteria; BAE77932; BAE77932; BAE77932.
DR   GeneID; 947866; -.
DR   KEGG; ecj:JW5701; -.
DR   KEGG; eco:b3358; -.
DR   PATRIC; fig|511145.12.peg.3452; -.
DR   EchoBASE; EB2743; -.
DR   eggNOG; COG1289; Bacteria.
DR   HOGENOM; CLU_025192_0_0_6; -.
DR   InParanoid; P45537; -.
DR   OMA; MRLWVTH; -.
DR   PhylomeDB; P45537; -.
DR   BioCyc; EcoCyc:G7721-MON; -.
DR   PRO; PR:P45537; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR010020; Integral_membrane_YCCS_YHJK.
DR   InterPro; IPR032692; YccS_N.
DR   Pfam; PF12805; FUSC-like; 1.
DR   TIGRFAMs; TIGR01667; YCCS_YHJK; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..700
FT                   /note="Uncharacterized protein YhfK"
FT                   /id="PRO_0000169523"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   700 AA;  79972 MW;  4E3532A1129AB6A7 CRC64;
     MFPPMWRRLI YHPDINYALR QTLVLCLPVA VGLMLGELRF GLLFSLVPAC CNIAGLDTPH
     KRFFKRLIIG ASLFATCSLL TQLLLAKDVP LPFLLTGLTL VLGVTAELGP LHAKLLPASL
     LAAIFTLSLA GYMPVWEPLL IYALGTLWYG LFNWFWFWIW REQPLRESLS LLYRELADYC
     EAKYSLLTQH TDPEKALPPL LVRQQKAVDL ITQCYQQMHM LSAQNNTDYK RMLRIFQEAL
     DLQEHISVSL HQPEEVQKLV ERSHAEEVIR WNAQTVAARL RVLADDILYH RLPTRFTMEK
     QIGALEKIAR QHPDNPVGQF CYWHFSRIAR VLRTQKPLYA RDLLADKQRR MPLLPALKSY
     LSLKSPALRN AGRLSVMLSV ASLMGTALHL PKSYWILMTV LLVTQNGYGA TRLRIVNRSV
     GTVVGLIIAG VALHFKIPEG YTLTLMLITT LASYLILRKN YGWATVGFTI TAVYTLQLLW
     LNGEQYILPR LIDTIIGCLI AFGGTVWLWP QWQSGLLRKN AHDALEAYQE AIRLILSEDP
     QPTPLAWQRM RVNQAHNTLY NSLNQAMQEP AFNSHYLADM KLWVTHSQFI VEHINAMTTL
     AREHRALPPE LAQEYLQSCE IAIQRCQQRL EYDEPGSSGD ANIMDAPEMQ PHEGAAGTLE
     QHLQRVIGHL NTMHTISSMA WRQRPHHGIW LSRKLRDSKA