ID   YHGN_ECOLI              Reviewed;         197 AA.
AC   P67143; P46851; Q2M798;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=UPF0056 inner membrane protein YhgN;
GN   Name=yhgN; OrderedLocusNames=b3434, JW3397;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the UPF0056 (MarC) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U18997; AAA58232.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76459.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77858.1; -; Genomic_DNA.
DR   PIR; E65139; E65139.
DR   RefSeq; NP_417892.1; NC_000913.3.
DR   RefSeq; WP_001002544.1; NZ_STEB01000004.1.
DR   AlphaFoldDB; P67143; -.
DR   BioGRID; 4259298; 183.
DR   STRING; 511145.b3434; -.
DR   TCDB; 2.A.95.1.5; the 6 tms neutral amino acid transporter (naat) family.
DR   PaxDb; P67143; -.
DR   PRIDE; P67143; -.
DR   EnsemblBacteria; AAC76459; AAC76459; b3434.
DR   EnsemblBacteria; BAE77858; BAE77858; BAE77858.
DR   GeneID; 66672682; -.
DR   GeneID; 947938; -.
DR   KEGG; ecj:JW3397; -.
DR   KEGG; eco:b3434; -.
DR   PATRIC; fig|1411691.4.peg.3294; -.
DR   EchoBASE; EB2776; -.
DR   eggNOG; COG2095; Bacteria.
DR   HOGENOM; CLU_079909_1_1_6; -.
DR   InParanoid; P67143; -.
DR   OMA; IRMIFPQ; -.
DR   PhylomeDB; P67143; -.
DR   BioCyc; EcoCyc:G7753-MON; -.
DR   PRO; PR:P67143; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   InterPro; IPR002771; Multi_antbiot-R_MarC.
DR   PANTHER; PTHR33508; PTHR33508; 1.
DR   Pfam; PF01914; MarC; 1.
DR   TIGRFAMs; TIGR00427; TIGR00427; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..197
FT                   /note="UPF0056 inner membrane protein YhgN"
FT                   /id="PRO_0000156902"
FT   TOPO_DOM        1..3
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..44
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..71
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..105
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..138
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..173
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..197
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   197 AA;  21490 MW;  C3A2B0223545B212 CRC64;
     MNEIISAAVL LILIMDPLGN LPIFMSVLKH TEPKRRRAIM VRELLIALLV MLVFLFAGEK
     ILAFLSLRAE TVSISGGIIL FLIAIKMIFP SASGNSSGLP AGEEPFIVPL AIPLVAGPTI
     LATLMLLSHQ YPNQMGHLVI ALLLAWGGTF VILLQSSLFL RLLGEKGVNA LERLMGLILV
     MMATQMFLDG IRMWMKG