YHH5_SCHPO
ID YHH5_SCHPO Reviewed; 276 AA.
AC Q9USV2; P78934;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Uncharacterized oxidoreductase C28F2.05;
DE EC=1.-.-.-;
GN ORFNames=SPBC28F2.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RA Kohnosu A., Niwa O., Yano M., Saitoh S., Katayama T., Nagao K.,
RA Yanagida M.;
RT "S.pombe chromosome II cosmid 1228 sequence.";
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR EMBL; D83992; BAA12182.1; -; Genomic_DNA.
DR EMBL; CU329671; CAB57934.1; -; Genomic_DNA.
DR PIR; T40048; T40048.
DR RefSeq; NP_595666.1; NM_001021561.2.
DR AlphaFoldDB; Q9USV2; -.
DR SMR; Q9USV2; -.
DR BioGRID; 277088; 5.
DR STRING; 4896.SPBC28F2.05c.1; -.
DR MaxQB; Q9USV2; -.
DR PaxDb; Q9USV2; -.
DR EnsemblFungi; SPBC28F2.05c.1; SPBC28F2.05c.1:pep; SPBC28F2.05c.
DR GeneID; 2540561; -.
DR KEGG; spo:SPBC28F2.05c; -.
DR PomBase; SPBC28F2.05c; -.
DR VEuPathDB; FungiDB:SPBC28F2.05c; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_1_1; -.
DR InParanoid; Q9USV2; -.
DR OMA; WSYLQGF; -.
DR PhylomeDB; Q9USV2; -.
DR PRO; PR:Q9USV2; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0032867; F:L-arabinose:NADP reductase activity; ISO:PomBase.
DR GO; GO:0019568; P:arabinose catabolic process; ISO:PomBase.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; PTHR43827; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Oxidoreductase; Reference proteome.
FT CHAIN 1..276
FT /note="Uncharacterized oxidoreductase C28F2.05"
FT /id="PRO_0000310313"
FT ACT_SITE 47
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 110
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT SITE 77
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000250"
FT CONFLICT 230
FT /note="F -> S (in Ref. 1; BAA12182)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 32046 MW; 55867685052226A1 CRC64;
MKPFSPSQTN FEKEQLCFGV YQLKDCYQQV IEALSLGIRV IDSAITYRNE KECEQAIQDF
CHQNVNIKRE DITLITKIPD SLQGFERTWK AVEQSLRRTG RPKLDVVLIH SPKWPVRRIE
SWRALLQHQK EGRINKIGVS NYNIHHLEEI ISLGLPLPAI NQVEFSAFNN RPTFLSYCFN
HGILVQAFSP LTRGYRLSDI RLLDLSLKYN KTPANILLRY CLQKGVSPIF KASSFVHIHE
NVKAEQFMLD PSDMDVMDTW DEEFVSKPTW NPIILP
