ID   YHHS_ECO57              Reviewed;         405 AA.
AC   Q8X6P4;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Uncharacterized MFS-type transporter YhhS {ECO:0000255|HAMAP-Rule:MF_01118};
GN   Name=yhhS; OrderedLocusNames=Z4847, ECs4322;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01118}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01118}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. YhhS family.
CC       {ECO:0000255|HAMAP-Rule:MF_01118}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG58582.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB37745.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG58582.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB37745.1; ALT_INIT; Genomic_DNA.
DR   PIR; B86015; B86015.
DR   PIR; B91169; B91169.
DR   RefSeq; NP_312349.2; NC_002695.1.
DR   RefSeq; WP_001412007.1; NZ_CP031913.1.
DR   AlphaFoldDB; Q8X6P4; -.
DR   SMR; Q8X6P4; -.
DR   STRING; 155864.EDL933_4686; -.
DR   EnsemblBacteria; AAG58582; AAG58582; Z4847.
DR   EnsemblBacteria; BAB37745; BAB37745; ECs_4322.
DR   GeneID; 915820; -.
DR   KEGG; ece:Z4847; -.
DR   KEGG; ecs:ECs_4322; -.
DR   PATRIC; fig|386585.9.peg.4515; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_10_3_6; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01118; MFS_YhhS; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023008; MFS_YhhS-like.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..405
FT                   /note="Uncharacterized MFS-type transporter YhhS"
FT                   /id="PRO_0000087809"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
SQ   SEQUENCE   405 AA;  42282 MW;  2C3B6DFD039498DB CRC64;
     MPEPVAEPAL NGLRLNLRIL SIVMFNFASY LTIGLPLAVL PGYVHDVMGF SAFWAGLVIS
     LQYFATLLSR PHAGRYADLL GPKKIVVFGL CGCFLSGLGY LTAGLTASLP VISLLLLCLG
     RVILGIGQSF AGTGSTLWGV GVVGSLHIGR VISWNDIVTY GAMAMGAPLG VVFYHWGGLQ
     ALALIIMGVA LVAILLAIPR PTVKASKGKP LPFRAVLGRV WLYGMALALA SAGFGVIATF
     ITLFYDVKGW DGAAFALTLF SCAFVGTRLL FPNGINRIGG LNVAMICFSV EIIGLLLVGV
     ATMPWMAKIG VLLAGAGFSL VFPALGVVAV KAVPQQNQGA ALATYTVFMD LSLGVTGPLA
     GLVMSWAGVP VIYLAAAGLV AIALLLTWRL KKRPPEHVPE AASSS