ID   YHHS_ECOL6              Reviewed;         405 AA.
AC   Q8FCN5;
DT   04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Uncharacterized MFS-type transporter YhhS {ECO:0000255|HAMAP-Rule:MF_01118};
GN   Name=yhhS; OrderedLocusNames=c4266;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01118}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01118}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. YhhS family.
CC       {ECO:0000255|HAMAP-Rule:MF_01118}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82702.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82702.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q8FCN5; -.
DR   SMR; Q8FCN5; -.
DR   STRING; 199310.c4266; -.
DR   EnsemblBacteria; AAN82702; AAN82702; c4266.
DR   KEGG; ecc:c4266; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_10_3_6; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01118; MFS_YhhS; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023008; MFS_YhhS-like.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..405
FT                   /note="Uncharacterized MFS-type transporter YhhS"
FT                   /id="PRO_0000087808"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
SQ   SEQUENCE   405 AA;  42158 MW;  1046BA3E0F709424 CRC64;
     MPEPVAEPAL NGLRLNLRIV SIVMFNFASY LTIGLPLAVL PGYVHDVMGF SAFWAGLVIS
     LQYFATLLSR PHAGRYADLL GPKKIVVFGL CGCFLSGLGY LTAGLTASLP VISLLLLCLG
     RVILGIGQSF AGTGSTLWGV GVVGSLHIGR VISWNGIVTY GAMAMGAPLG VVFYHWGGLQ
     ALALIIMGVA LVAILLAIPR PTVKASKGKP LPFRAVLGRV WLYGMALALA SAGFGVIATF
     ITLFYDAKGW DGAAFALTLF SCAFVGTRLL FPNGINRIGG LNVAMICFSV EIIGLLLVGV
     ATMPWMAKIG VLLAGAGFSL VFPALGVVAV KAVPQQNQGA ALATYTVFMD LSLGVTGPLA
     GLVMSWAGVP VIYLAAAGLV AIALLLTWRL KKRPPVEIPE AASSS