ID   YHHS_SALTY              Reviewed;         405 AA.
AC   Q8ZLE4;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Uncharacterized MFS-type transporter YhhS {ECO:0000255|HAMAP-Rule:MF_01118};
GN   Name=yhhS; OrderedLocusNames=STM3581;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01118}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01118}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. YhhS family.
CC       {ECO:0000255|HAMAP-Rule:MF_01118}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL22441.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE006468; AAL22441.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_462482.3; NC_003197.2.
DR   AlphaFoldDB; Q8ZLE4; -.
DR   SMR; Q8ZLE4; -.
DR   STRING; 99287.STM3581; -.
DR   PaxDb; Q8ZLE4; -.
DR   EnsemblBacteria; AAL22441; AAL22441; STM3581.
DR   GeneID; 1255104; -.
DR   KEGG; stm:STM3581; -.
DR   PATRIC; fig|99287.12.peg.3784; -.
DR   HOGENOM; CLU_001265_10_3_6; -.
DR   OMA; IMVFFAP; -.
DR   PhylomeDB; Q8ZLE4; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01118; MFS_YhhS; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023008; MFS_YhhS-like.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..405
FT                   /note="Uncharacterized MFS-type transporter YhhS"
FT                   /id="PRO_0000087811"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
SQ   SEQUENCE   405 AA;  42083 MW;  A812740F51E06AE4 CRC64;
     MPEPVAEPAL NGLRLNLRIV SIVMFNFASY LTIGLPLAVL PGYVHDAMGF SAFWAGLIIS
     LQYFATLLSR PHAGRYADVL GPKKIVVFGL CGCFLSGLGY LLADIASAWP MISLLLLGLG
     RVILGIGQSF AGTGSTLWGV GVVGSLHIGR VISWNGIVTY GAMAMGAPLG VLCYAWGGLQ
     GLALTVMGVA LLAVLLALPR PSVKANKGKP LPFRAVLGRV WLYGMALALA SAGFGVIATF
     ITLFYDAKGW DGAAFALTLF SVAFVGTRLL FPNGINRLGG LNVAMICFGV EIIGLLLVGT
     AAMPWMAKIG VLLTGMGFSL VFPALGVVAV KAVPPQNQGA ALATYTVFMD MSLGVTGPLA
     GLVMTWAGVP VIYLAAAGLV AMALLLTWRL KKRPPSALPE AASSS