YHHS_SHIFL
ID YHHS_SHIFL Reviewed; 405 AA.
AC P59195;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Uncharacterized MFS-type transporter YhhS {ECO:0000255|HAMAP-Rule:MF_01118};
GN Name=yhhS; OrderedLocusNames=SF3491, S4272;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01118}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01118}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. YhhS family.
CC {ECO:0000255|HAMAP-Rule:MF_01118}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN44950.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP19232.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN44950.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP19232.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_709243.3; NC_004337.2.
DR RefSeq; WP_001309018.1; NZ_WPGW01000010.1.
DR AlphaFoldDB; P59195; -.
DR SMR; P59195; -.
DR STRING; 198214.SF3491; -.
DR EnsemblBacteria; AAN44950; AAN44950; SF3491.
DR EnsemblBacteria; AAP19232; AAP19232; S4272.
DR GeneID; 1026413; -.
DR KEGG; sfl:SF3491; -.
DR KEGG; sfx:S4272; -.
DR PATRIC; fig|198214.7.peg.4112; -.
DR HOGENOM; CLU_001265_10_3_6; -.
DR OrthoDB; 626204at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01118; MFS_YhhS; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023008; MFS_YhhS-like.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..405
FT /note="Uncharacterized MFS-type transporter YhhS"
FT /id="PRO_0000087812"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
SQ SEQUENCE 405 AA; 42182 MW; DD28253E0F709436 CRC64;
MPEPVAEPAL NGLRLNLRIV SIVMFNFASY LTIGLPLAVL PGYVHDVMGF SAFWAGLVIS
LQYFATLLSR PHAGRYADLL GPKKIVVFGL CGCFLSGLGY LTAGLTASLP VISLLLLCLG
RVILGIGQSF AGTGSTLWGV GVVGSLHIGR VISWNGIVTY GAMAMGAPLG VVFYHWGGLQ
ALALIIMGVA LVAILLAIPR PTVKASKGKP LPFRAVLGRV WLYGMALALA SAGFGVIATF
ITLFYDAKGW DGAAFALTLF SCAFVGTRLL FPNGINRIGG LNVAMICFSV EIIGLLLVGV
ATMPWMAKIG VLLAGAGFSL VFPALGVVAV KAVPQQNQGA ALATYTVFMD LSLGVTGPLA
GLVMSWAGVP VIYLAAAGLV AIALLLTWRL KKRPPEHVPE AASSS
