YHI9_YEAST
ID YHI9_YEAST Reviewed; 294 AA.
AC P38765; D3DKX6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Uncharacterized isomerase YHI9;
DE EC=5.1.-.-;
GN Name=YHI9; OrderedLocusNames=YHR029C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=16582425; DOI=10.1534/genetics.106.057489;
RA Hancock L.C., Behta R.P., Lopes J.M.;
RT "Genomic analysis of the Opi- phenotype.";
RL Genetics 173:621-634(2006).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
RX PubMed=16021630; DOI=10.1002/prot.20548;
RA Liger D., Quevillon-Cheruel S., Sorel I., Bremang M., Blondeau K.,
RA Aboulfath I., Janin J., van Tilbeurgh H., Leulliot N.;
RT "Crystal structure of YHI9, the yeast member of the phenazine biosynthesis
RT PhzF enzyme superfamily.";
RL Proteins 60:778-786(2005).
CC -!- DISRUPTION PHENOTYPE: Leads to defects in unfolded protein response.
CC {ECO:0000269|PubMed:16582425}.
CC -!- SIMILARITY: Belongs to the PhzF family. {ECO:0000305}.
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DR EMBL; U10399; AAB68880.1; -; Genomic_DNA.
DR EMBL; AY557826; AAS56152.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06720.1; -; Genomic_DNA.
DR PIR; S46781; S46781.
DR RefSeq; NP_011894.1; NM_001179159.1.
DR PDB; 1YM5; X-ray; 2.05 A; A=1-294.
DR PDBsum; 1YM5; -.
DR AlphaFoldDB; P38765; -.
DR SMR; P38765; -.
DR BioGRID; 36460; 71.
DR IntAct; P38765; 12.
DR MINT; P38765; -.
DR STRING; 4932.YHR029C; -.
DR MaxQB; P38765; -.
DR PaxDb; P38765; -.
DR PRIDE; P38765; -.
DR EnsemblFungi; YHR029C_mRNA; YHR029C; YHR029C.
DR GeneID; 856424; -.
DR KEGG; sce:YHR029C; -.
DR SGD; S000001071; YHI9.
DR VEuPathDB; FungiDB:YHR029C; -.
DR eggNOG; KOG3033; Eukaryota.
DR GeneTree; ENSGT00390000017595; -.
DR HOGENOM; CLU_048756_0_0_1; -.
DR InParanoid; P38765; -.
DR OMA; CHAWLQA; -.
DR BioCyc; YEAST:G3O-31089-MON; -.
DR ChiTaRS; YHI9; yeast.
DR EvolutionaryTrace; P38765; -.
DR PRO; PR:P38765; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38765; protein.
DR GO; GO:0000785; C:chromatin; IDA:SGD.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016853; F:isomerase activity; IBA:GO_Central.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:SGD.
DR InterPro; IPR003719; Phenazine_PhzF.
DR PANTHER; PTHR13774; PTHR13774; 1.
DR Pfam; PF02567; PhzC-PhzF; 1.
DR PIRSF; PIRSF016184; PhzC_PhzF; 1.
DR TIGRFAMs; TIGR00654; PhzF_family; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Isomerase; Reference proteome.
FT CHAIN 1..294
FT /note="Uncharacterized isomerase YHI9"
FT /id="PRO_0000162387"
FT ACT_SITE 52
FT /evidence="ECO:0000250"
FT STRAND 3..12
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 19..27
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 33..35
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 38..48
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 65..71
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 81..94
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 101..107
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 110..117
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 120..124
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 129..132
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 135..145
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 154..166
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 170..175
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 180..190
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 194..200
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 209..216
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 217..219
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 221..226
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 228..242
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 248..254
FT /evidence="ECO:0007829|PDB:1YM5"
FT HELIX 256..258
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 262..270
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 276..282
FT /evidence="ECO:0007829|PDB:1YM5"
FT STRAND 284..294
FT /evidence="ECO:0007829|PDB:1YM5"
SQ SEQUENCE 294 AA; 32563 MW; ADD1315AF7DA60E9 CRC64;
MTLMVPFKQV DVFTEKPFMG NPVAVINFLE IDENEVSQEE LQAIANWTNL SETTFLFKPS
DKKYDYKLRI FTPRSELPFA GHPTIGSCKA FLEFTKNTTA TSLVQECKIG AVPITINEGL
ISFKAPMADY ESISSEMIAD YEKAIGLKFI KPPALLHTGP EWIVALVEDA ETCFNANPNF
AMLAHQTKQN DHVGIILAGP KKEAAIKNSY EMRAFAPVIN VYEDPVCGSG SVALARYLQE
VYKFEKTTDI TISEGGRLKR NGLMLASIKK EADNSTSYYI AGHATTVIDG KIKV
