YHLA_SCHPO
ID YHLA_SCHPO Reviewed; 1116 AA.
AC Q9HGL2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized calcium-binding protein C800.10c;
GN ORFNames=SPBC800.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAC01525.1; -; Genomic_DNA.
DR RefSeq; NP_595112.1; NM_001021019.2.
DR AlphaFoldDB; Q9HGL2; -.
DR SMR; Q9HGL2; -.
DR BioGRID; 277342; 1.
DR STRING; 4896.SPBC800.10c.1; -.
DR iPTMnet; Q9HGL2; -.
DR MaxQB; Q9HGL2; -.
DR PaxDb; Q9HGL2; -.
DR PRIDE; Q9HGL2; -.
DR EnsemblFungi; SPBC800.10c.1; SPBC800.10c.1:pep; SPBC800.10c.
DR GeneID; 2540824; -.
DR KEGG; spo:SPBC800.10c; -.
DR PomBase; SPBC800.10c; -.
DR VEuPathDB; FungiDB:SPBC800.10c; -.
DR eggNOG; KOG0998; Eukaryota.
DR HOGENOM; CLU_285772_0_0_1; -.
DR InParanoid; Q9HGL2; -.
DR OMA; WDEIFAG; -.
DR PhylomeDB; Q9HGL2; -.
DR Reactome; R-SPO-416482; G alpha (12/13) signalling events.
DR Reactome; R-SPO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-SPO-9013148; CDC42 GTPase cycle.
DR Reactome; R-SPO-9013420; RHOU GTPase cycle.
DR PRO; PR:Q9HGL2; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030479; C:actin cortical patch; ISO:PomBase.
DR GO; GO:0005938; C:cell cortex; HDA:PomBase.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0035838; C:growing cell tip; IDA:PomBase.
DR GO; GO:0005509; F:calcium ion binding; ISM:PomBase.
DR GO; GO:0000147; P:actin cortical patch assembly; ISO:PomBase.
DR GO; GO:0044396; P:actin cortical patch organization; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; ISO:PomBase.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR CDD; cd00052; EH; 3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR Pfam; PF12763; EF-hand_4; 3.
DR SMART; SM00054; EFh; 3.
DR SMART; SM00027; EH; 3.
DR SUPFAM; SSF47473; SSF47473; 3.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 4.
DR PROSITE; PS50031; EH; 3.
PE 4: Predicted;
KW Calcium; Coiled coil; Cytoplasm; Cytoskeleton; Metal-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..1116
FT /note="Uncharacterized calcium-binding protein C800.10c"
FT /id="PRO_0000310332"
FT DOMAIN 8..43
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 9..106
FT /note="EH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 42..77
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 134..224
FT /note="EH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 166..201
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 259..348
FT /note="EH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 292..327
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 360..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 565..707
FT /evidence="ECO:0000255"
FT COMPBIAS 380..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 305
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 307
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 309
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 311
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 316
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 1116 AA; 120541 MW; 79F1941C4CEBAAF9 CRC64;
MSLNLSAEEQ TAFDQLFKIA DKQDIGVITG EEAVPFLEKS GLAPQVLGQI WQIADAENRG
FLTFSGFVIA MRLVALAQEK LPFDYKKSGK IPYFADIHIS GVDSSKFVQL NRPNNVSSGD
GSDGSFLPPI SSDEMTRYQQ MFTTVCPTDG LMDGDRASSI FGRAPLSTEI LARVWNLVDT
HKRGALDIRE FNTGMHIINL LLNGSLKSPP VSISPSFIAS AASTSSVSAP SQYPGLSRSP
PVQAPNIPVS DPWAIPSQDL TSFCQLFSNV DKAHKGYVSG SEAYSFFLAS KLPEDVLAQI
WDLSDTNSNG KLNIGEFCIS LYLIKLKLSG KELPKVLPSS MLSSVAPLMQ KSKSVPTSIP
SVVPANISSP NPNPTLAPNP TGPSRVTSGT EDLLSLDATP FSPTLAPQHT SSNATKHSAP
PVTKSAPFPV VSPLQLNHTP GFPTSPAAKP NSPTSTFFPQ SSFGQTIAKN TMDKPSAVRT
SVPSQLAAPI PQVASAEQLK LAAEVPKLES QLSQVKKSND DLQKSSRDVA ANLSDVKAKV
SEIRKAYDEE LAKAKQISLD IETNKAQTEQ VNREYSILEA TLNALQKQNK QKGEVLEQVV
AESEAAKNMV ESSNASIQQL KSEVADKEQT LAQLHLQLDE MTQRLVSLDE ESKAVSQRKL
DLEYKINNSK TQLATATEEY HEHSKQLEAE KQELSKLEDG LKSVNLTEEA PKPEVDSTPR
FPSFTSNGIT TDKPTLPDTT SSVPTQHNSF DAMHNTLRSP SLNSNNSSAH ASTVSRNPFH
NLKISGASSP VSNFWESEFA SAVFPRSISK TTSLSVNNSS VNPSLDSEPV QLSNMEEPQH
QDSSVVDVST SASQRGSPVL SDLSKLTGSA RNTAEPVENT SAEPIENTSA PTPFEIANKQ
QATEPISAPF ATETISTPAP VKPPVPPSRR DRSAQDGVVQ QATPHIQDEF PPIQFNEIDD
DESSSDEEPP MSNLSPQISI GSVTNYTSAV TELPDPNHQL EMSTTTHVQH PNSETIPSST
ENQYFDTTSG AFEANSNTEV TVNSNEVSQP FDFDTANESD NDDDELPVQQ VVSGSLANDA
FNVDDEFDNQ FANLQAAEIK DDDNSSTDEE EHAGHH
