ID   YHMF_METFE              Reviewed;         285 AA.
AC   P19268;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Uncharacterized 32.2 kDa protein in hmfB 3'region;
OS   Methanothermus fervidus.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=2180;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2377617; DOI=10.1073/pnas.87.15.5788;
RA   Sandman K.M., Krzycki J.A., Dobrinski B., Lurz R., Reeve J.N.;
RT   "HMf, a DNA-binding protein isolated from the hyperthermophilic archaeon
RT   Methanothermus fervidus, is most closely related to histones.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:5788-5791(1990).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00742};
CC   -!- SIMILARITY: Belongs to the arginase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00742}.
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DR   EMBL; M34778; AAA72081.1; -; Genomic_DNA.
DR   RefSeq; WP_013414264.1; NC_014658.1.
DR   AlphaFoldDB; P19268; -.
DR   SMR; P19268; -.
DR   PRIDE; P19268; -.
DR   GeneID; 9962948; -.
DR   OMA; YELTTIM; -.
DR   GO; GO:0016813; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR   InterPro; IPR005925; Agmatinase-rel.
DR   InterPro; IPR006035; Ureohydrolase.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR   PANTHER; PTHR11358; PTHR11358; 1.
DR   Pfam; PF00491; Arginase; 1.
DR   PIRSF; PIRSF036979; Arginase; 1.
DR   SUPFAM; SSF52768; SSF52768; 1.
DR   TIGRFAMs; TIGR01230; agmatinase; 1.
DR   PROSITE; PS01053; ARGINASE_1; 1.
DR   PROSITE; PS51409; ARGINASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Metal-binding.
FT   CHAIN           1..285
FT                   /note="Uncharacterized 32.2 kDa protein in hmfB 3'region"
FT                   /id="PRO_0000173785"
FT   BINDING         110
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         131
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         131
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         133
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         135
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         214
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         214
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
FT   BINDING         216
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00742"
SQ   SEQUENCE   285 AA;  32227 MW;  79E1934258502CD7 CRC64;
     MGLKFAYSKD PSSLKYLSNK KVFGLLGVPF DSTSTYKPGS RFGPLMIRQA SYNFENYSLH
     YRKKLDVPII DLGDIEVILG DFKNTCRNIS EKVQEVLKKG MIPIVLGGEH SITYGVVKTF
     DLSDVTILHF DAHMDMANTY AGKKFSHATV MRRIYELHPK KIVQIGVRSC TKEEHEFVLN
     ENIKYYTSRD IIEKFNMVLN EINKLDGPFY VTVDIDVLDP GYAPGVGNPT PVGITPYHME
     KFIEKIARKK IIGIDIVEVA TDRIGDPAAM NAAKILYDFL FAIKI