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YHP1_YEAST
ID   YHP1_YEAST              Reviewed;         353 AA.
AC   Q04116; D6VT76;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Homeobox protein YHP1;
GN   Name=YHP1; OrderedLocusNames=YDR451C; ORFNames=D9461.36;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   INDUCTION.
RX   PubMed=11097841; DOI=10.1006/bbrc.2000.3800;
RA   Kunoh T., Kaneko Y., Harashima S.;
RT   "Positive regulation of transcription of homeoprotein-encoding YHP1 by the
RT   two-component regulator Sln1 in Saccharomyces cerevisiae.";
RL   Biochem. Biophys. Res. Commun. 278:344-348(2000).
RN   [4]
RP   POSSIBLE FUNCTION, AND DNA-BINDING.
RX   PubMed=10705372;
RX   DOI=10.1002/(sici)1097-0061(20000330)16:5<439::aid-yea536>3.0.co;2-m;
RA   Kunoh T., Kaneko Y., Harashima S.;
RT   "YHP1 encodes a new homeoprotein that binds to the IME1 promoter in
RT   Saccharomyces cerevisiae.";
RL   Yeast 16:439-449(2000).
RN   [5]
RP   INDUCTION.
RX   PubMed=12464632; DOI=10.1101/gad.1039602;
RA   Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S.,
RA   Gerstein M., Snyder M.;
RT   "Complex transcriptional circuitry at the G1/S transition in Saccharomyces
RT   cerevisiae.";
RL   Genes Dev. 16:3017-3033(2002).
RN   [6]
RP   FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, AND INTERACTION WITH MCM1.
RX   PubMed=12464633; DOI=10.1101/gad.1034302;
RA   Pramila T., Miles S., GuhaThakurta D., Jemiolo D., Breeden L.L.;
RT   "Conserved homeodomain proteins interact with MADS box protein Mcm1 to
RT   restrict ECB-dependent transcription to the M/G1 phase of the cell cycle.";
RL   Genes Dev. 16:3034-3045(2002).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17287358; DOI=10.1073/pnas.0607084104;
RA   Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
RA   Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
RT   "Analysis of phosphorylation sites on proteins from Saccharomyces
RT   cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
CC   -!- FUNCTION: Transcriptional repressor required to restrict transcription
CC       of ECB-dependent genes to the G1/M phase by repressing their
CC       transcription during S late phase. Genes that contain a ECB (early cell
CC       box) element in their transcription regulatory region are transcribed
CC       only during G1/M phases. Binds the IMEI regulatory region in vitro, its
CC       relevance in vivo is however unclear. {ECO:0000269|PubMed:12464633}.
CC   -!- SUBUNIT: Interacts with MCM1. {ECO:0000269|PubMed:12464633}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed during late S phase and G2 phases.
CC       {ECO:0000269|PubMed:12464633}.
CC   -!- INDUCTION: May be regulated by MCM1. Regulated by SWI4-SWI6
CC       heterodimer. Down-regulated by nonfermentable carbon source.
CC       {ECO:0000269|PubMed:11097841, ECO:0000269|PubMed:12464632}.
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DR   EMBL; U33007; AAB64873.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA12286.1; -; Genomic_DNA.
DR   PIR; S69730; S69730.
DR   RefSeq; NP_010739.3; NM_001180759.3.
DR   AlphaFoldDB; Q04116; -.
DR   SMR; Q04116; -.
DR   BioGRID; 32506; 81.
DR   IntAct; Q04116; 13.
DR   MINT; Q04116; -.
DR   STRING; 4932.YDR451C; -.
DR   iPTMnet; Q04116; -.
DR   PaxDb; Q04116; -.
DR   PRIDE; Q04116; -.
DR   TopDownProteomics; Q04116; -.
DR   EnsemblFungi; YDR451C_mRNA; YDR451C; YDR451C.
DR   GeneID; 852062; -.
DR   KEGG; sce:YDR451C; -.
DR   SGD; S000002859; YHP1.
DR   VEuPathDB; FungiDB:YDR451C; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000176720; -.
DR   HOGENOM; CLU_043444_0_0_1; -.
DR   InParanoid; Q04116; -.
DR   OMA; IFEDHHI; -.
DR   BioCyc; YEAST:G3O-29982-MON; -.
DR   PRO; PR:Q04116; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q04116; protein.
DR   GO; GO:0000785; C:chromatin; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:SGD.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR   GO; GO:0071930; P:negative regulation of transcription involved in G1/S transition of mitotic cell cycle; IGI:SGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..353
FT                   /note="Homeobox protein YHP1"
FT                   /id="PRO_0000049386"
FT   DNA_BIND        173..232
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          86..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         315
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17287358"
SQ   SEQUENCE   353 AA;  39598 MW;  FD554F260CFA0E56 CRC64;
     MESRNTVLPS LPNIITGTSN SPFQLHTLPN TNFPSDDQGD IRLPPLAASA HIVRPVVNIY
     KSPCDEERPK RKSPQAVDFL SQRVTTSMTP LSKPKKLSSH SPFTPTVRVC SKEQPPQSMH
     SYKKVNILTP LSAAKAVLTP TTRKEKKRSF AFITHSQETF PKKEPKIDNA RLARRKRRRT
     SSYELGILQT AFDECPTPNK AKRIELSEQC NMSEKSVQIW FQNKRQAAKK HKNSGNTSHC
     KVHSNDSMSM ISYSDAALEI TSTPTSTKEA ITAELLKTSP ANTSSIFEDH HITPCKPGGQ
     LKFHRKSVLV KRTLSNTGHS EIIKSPKGKE NRLKFNAYER KPLGEVDLNS FKN
 
 
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