ID   YHR2_YEAST              Reviewed;         378 AA.
AC   P38716; D3DL62;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Uncharacterized trans-sulfuration enzyme YHR112C;
GN   OrderedLocusNames=YHR112C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000305}.
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DR   EMBL; U00059; AAB68864.1; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06806.1; -; Genomic_DNA.
DR   PIR; S48954; S48954.
DR   RefSeq; NP_011980.1; NM_001179242.1.
DR   AlphaFoldDB; P38716; -.
DR   SMR; P38716; -.
DR   BioGRID; 36545; 76.
DR   DIP; DIP-2850N; -.
DR   IntAct; P38716; 12.
DR   MINT; P38716; -.
DR   STRING; 4932.YHR112C; -.
DR   iPTMnet; P38716; -.
DR   MaxQB; P38716; -.
DR   PaxDb; P38716; -.
DR   PRIDE; P38716; -.
DR   EnsemblFungi; YHR112C_mRNA; YHR112C; YHR112C.
DR   GeneID; 856512; -.
DR   KEGG; sce:YHR112C; -.
DR   SGD; S000001154; YHR112C.
DR   VEuPathDB; FungiDB:YHR112C; -.
DR   eggNOG; KOG0053; Eukaryota.
DR   HOGENOM; CLU_018986_3_0_1; -.
DR   InParanoid; P38716; -.
DR   OMA; DWTKQLF; -.
DR   BioCyc; YEAST:G3O-31154-MON; -.
DR   PRO; PR:P38716; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38716; protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IBA:GO_Central.
DR   GO; GO:0004121; F:cystathionine beta-lyase activity; ISS:SGD.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   GO; GO:0006790; P:sulfur compound metabolic process; ISS:SGD.
DR   GO; GO:0019346; P:transsulfuration; IBA:GO_Central.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808; PTHR11808; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   1: Evidence at protein level;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..378
FT                   /note="Uncharacterized trans-sulfuration enzyme YHR112C"
FT                   /id="PRO_0000114766"
FT   MOD_RES         198
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   378 AA;  42445 MW;  3300336DCC20EE5E CRC64;
     MVDLSTALIH GDDKDNRVTD VAPPINVSTT FRYDDDDLIP WTERENLDFM EKKPVYSRLA
     HPNSTRLESI FSEILDGYAV IYSSGLAAFY AAMVHYNPKK IFIGQSYHGV RAIANILTRN
     YGIEQHPLED IEKCASEGDI VHLESPVNPY GTSSDIESLA RRAHAKGALL IVDSTFASPP
     LQYAWNFGAD IVLYSATKYF GGHSDLLSGV LVVKEEATSR QLKDDRIYLG TNVANLESFM
     LLRSLRTYEM RITKQSENAT KLVRFLSDHQ SEFDKVLKTI YHSSLQTEEF VKKQLVGGYG
     PVFAITLYTK EQCKQLPLKL KYFHHATSLG GIESLVEWRA MTDPYIDQTL IRVSVGCESA
     NDLIKDLASA LKELQDAA