YHS2_YEAST
ID YHS2_YEAST Reviewed; 231 AA.
AC P38829; D3DL72;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=MIP18 family protein YHR122W;
GN OrderedLocusNames=YHR122W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP FUNCTION.
RX PubMed=18439903; DOI=10.1016/j.molcel.2008.02.021;
RA Ben-Aroya S., Coombes C., Kwok T., O'Donnell K.A., Boeke J.D., Hieter P.;
RT "Toward a comprehensive temperature-sensitive mutant repository of the
RT essential genes of Saccharomyces cerevisiae.";
RL Mol. Cell 30:248-258(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: May play a role in chromosome segregation through
CC establishment of sister chromatid cohesion.
CC {ECO:0000269|PubMed:18439903}.
CC -!- INTERACTION:
CC P38829; Q05583: CIA1; NbExp=4; IntAct=EBI-24704, EBI-32145;
CC P38829; P40469: MET18; NbExp=4; IntAct=EBI-24704, EBI-11492;
CC -!- MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the MIP18 family. {ECO:0000305}.
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DR EMBL; U10398; AAB68410.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06816.1; -; Genomic_DNA.
DR PIR; S48966; S48966.
DR RefSeq; NP_011990.1; NM_001179252.1.
DR AlphaFoldDB; P38829; -.
DR SMR; P38829; -.
DR BioGRID; 36555; 197.
DR DIP; DIP-1837N; -.
DR IntAct; P38829; 115.
DR MINT; P38829; -.
DR STRING; 4932.YHR122W; -.
DR iPTMnet; P38829; -.
DR MaxQB; P38829; -.
DR PaxDb; P38829; -.
DR PRIDE; P38829; -.
DR EnsemblFungi; YHR122W_mRNA; YHR122W; YHR122W.
DR GeneID; 856522; -.
DR KEGG; sce:YHR122W; -.
DR SGD; S000001164; YHR122W.
DR VEuPathDB; FungiDB:YHR122W; -.
DR eggNOG; KOG3381; Eukaryota.
DR GeneTree; ENSGT00390000017697; -.
DR HOGENOM; CLU_075876_1_1_1; -.
DR InParanoid; P38829; -.
DR OMA; GTHNSEN; -.
DR BioCyc; YEAST:G3O-31164-MON; -.
DR PRO; PR:P38829; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38829; protein.
DR GO; GO:0097361; C:CIA complex; IDA:SGD.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:SGD.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IEA:InterPro.
DR Gene3D; 3.30.300.130; -; 1.
DR InterPro; IPR034904; FSCA_dom_sf.
DR InterPro; IPR039796; MIP18.
DR InterPro; IPR002744; MIP18-like.
DR PANTHER; PTHR12377; PTHR12377; 1.
DR Pfam; PF01883; FeS_assembly_P; 1.
DR SUPFAM; SSF117916; SSF117916; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chromosome partition; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..231
FT /note="MIP18 family protein YHR122W"
FT /id="PRO_0000212699"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 231 AA; 25675 MW; 0C5AF75D54C77BCA CRC64;
MSEFLNENPD ILEENQLPTR KEDSTKDLLL GGFSNEATLE RRSLLLKIDH SLKSQVLQDI
EVLDKLLSIR IPPELTSDED SLPAESEDES VAGGGKEEEE PDLIDAQEIY DLIAHISDPE
HPLSLGQLSV VNLEDIDVHD SGNQNEMAEV VIKITPTITH CSLATLIGLG IRVRLERSLP
PRFRITILLK KGTHDSENQV NKQLNDKERV AAACENEQLL GVVSKMLVTC K
