ID   YHTH1_STAAU             Reviewed;         745 AA.
AC   Q936F1; Q936E9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49951 / M / NCTC 10649;
RX   PubMed=12057957; DOI=10.1128/jb.184.13.3623-3629.2002;
RA   Luong T.T., Ouyang S., Bush K., Lee C.Y.;
RT   "Type 1 capsule genes of Staphylococcus aureus are carried in a
RT   staphylococcal cassette chromosome genetic element.";
RL   J. Bacteriol. 184:3623-3629(2002).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL26687.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAL26689.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U10927; AAL26687.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U10927; AAL26689.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q936F1; -.
DR   SMR; Q936F1; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..745
FT                   /note="Uncharacterized HTH-type transcriptional regulator"
FT                   /id="PRO_0000194632"
FT   DOMAIN          158..256
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        175..196
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        223..246
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   745 AA;  87842 MW;  3D65DA6E6E3E4624 CRC64;
     MQRDYLIRVE TESMSDFKRL NGLMIGFVIK GEAHIYDENN MTQCNSGDIF IINHRDLYRF
     QLQQDGIICY IQFQMKYLAD KFDDAHCLYF HLTDATTTKN KHQLRNIMAR LVSTHIRHNE
     LSKLTEQQLV IQLLMHMIHY VPRTYHSNQS ILNDDKVNQV CDYIELHFHE DLSLSELSEY
     VGWSESHLSK KFAESLGVGF QHFLNTTRIE HAKLDLTYTD EMITDIALQN GFSSAASFAR
     TFKHITHQTP KQYRGDRPAV TENQQSAQHD YHDRELILLL NDYIEEMNHF IEDIEMMNYK
     EITFQPTNQQ LNQFNHIIQV GYLRNLLNTQ YQSQLLTCHH DFQVNEVLAY DVMPYIMKKL
     NAPFTYDAEI SNIFYDIDLC LDFLLDHNFS LTMHLDQYDS RDYIDAFKVF IHHVALHVSH
     RKDLKFNLYV TTLHTSLIEM IDYFKALFPN GGLYIHLDQA TERQLPLLKR LEPHIDHFVF
     DANSNNAVDF NKMNDDEFKT ASQMIINKTN YLIDLMHRHH LKRPLILLNW NTLTGDTFIT
     NGECFRGGII IEQLLKLSSK VEGIGYWLNY DLHVSHCRNE RDYMNSIELF HQYNGKRPVY
     FTALLFNKLT SNILYSDDTC IVTGTDSNFQ ILLYDAKHFN PYLALDNQMN MRATEMIHLN
     INALEEGMYK IKHFTLDKEN GALFNLWRKH HTIHGMDKDS IDYVNRMSFP KLEVYDIDMT
     DTLALNIKMI TNGIHLIEVK RYPSS