ID   YHX4_SCHPO              Reviewed;         530 AA.
AC   G2TRT0;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Synembryn-like protein C3E7.04c;
GN   ORFNames=SPBC3E7.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the synembryn family. {ECO:0000305}.
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DR   EMBL; CU329671; CAO77665.2; -; Genomic_DNA.
DR   RefSeq; XP_004001720.1; XM_004001671.1.
DR   AlphaFoldDB; G2TRT0; -.
DR   SMR; G2TRT0; -.
DR   STRING; 4896.SPBC3E7.04c.1; -.
DR   MaxQB; G2TRT0; -.
DR   PaxDb; G2TRT0; -.
DR   EnsemblFungi; SPBC3E7.04c.1; SPBC3E7.04c.1:pep; SPBC3E7.04c.
DR   PomBase; SPBC3E7.04c; -.
DR   VEuPathDB; FungiDB:SPBC3E7.04c; -.
DR   eggNOG; KOG4464; Eukaryota.
DR   HOGENOM; CLU_514035_0_0_1; -.
DR   InParanoid; G2TRT0; -.
DR   OMA; INAILEC; -.
DR   PRO; PR:G2TRT0; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISM:PomBase.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:PomBase.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019318; Gua_nucleotide_exch_fac_Ric8.
DR   PANTHER; PTHR12425; PTHR12425; 1.
DR   Pfam; PF10165; Ric8; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..530
FT                   /note="Synembryn-like protein C3E7.04c"
FT                   /id="PRO_0000416682"
FT   TRANSMEM        492..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   530 AA;  60627 MW;  F0A046218F4B3C1A CRC64;
     MELEAYIQSL GLGIESYSQS ATQFHDEANQ SFNIPISTII KLKEACRELE TSKVVAKSLN
     WSHLLRVISL LWEKDVSLEL MKLLANCLRQ VPSISVQIVH NESLKQLTTS VFEVRAPKVL
     SLISTFNDDL ERRVVFMRFL FILLSTQTDD ICLDMRQVRT QLIQMLKKMW TLNSSPSNNS
     QDNEMVLTEI LRLLFPISKR SYLKEEDEQK ILLLVIEIWA SSLNNNPNSP LRWHATNALL
     SFNLQLLSLD QAIYVSEIAC QTLQSILISR EVEYLEKGLN LCFDIAAKYQ NTLPPILAIL
     LSLLSFFNIK QNLSMLLFPT NDDRKQSLQK GKSFRCLLLR LLTIPIVEPI GTYYASLLNE
     LCDGDSQQIA RIFGAGYAMG ISQHSETMPF PSPLSKAASP VFQKNSRGQE NTEENNLAID
     PITGSMCTNR NKSQRLELSQ EEKEREAERL FYLFQRLEKN STIQVTNPIQ QAVNSGFIDV
     VFCLIFQMSS ESFIYHCYHS FVGPIHILLL MFSTFKFHEI LHFIKISKAS