ID   YHXA_BACSU              Reviewed;         450 AA.
AC   P33189; O07526;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 4.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Uncharacterized aminotransferase YhxA;
DE            EC=2.6.-.-;
GN   Name=yhxA; OrderedLocusNames=BSU09260;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA   Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA   Venema G., Bron S.;
RT   "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT   subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT   many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL   Microbiology 144:859-875(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 424-425.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-189.
RC   STRAIN=168;
RX   PubMed=8969498; DOI=10.1099/13500872-142-11-3021;
RA   Noback M.A., Terpstra P., Holsappel S., Venema G., Bron S.;
RT   "A 22 kb DNA sequence in the cspB-glpPFKD region at 75 degrees on the
RT   Bacillus subtilis chromosome.";
RL   Microbiology 142:3021-3026(1996).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 352-450.
RX   PubMed=8436953; DOI=10.1099/00221287-139-2-349;
RA   Beijer L., Nilsson R.-P., Holmberg C., Rutberg L.;
RT   "The glpP and glpF genes of the glycerol regulon in Bacillus subtilis.";
RL   J. Gen. Microbiol. 139:349-359(1993).
CC   -!- FUNCTION: Essential for glycerol catabolism.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000305}.
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DR   EMBL; Y14079; CAA74426.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12754.2; -; Genomic_DNA.
DR   EMBL; X96983; CAA65709.1; -; Genomic_DNA.
DR   EMBL; M99611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B69835; B69835.
DR   RefSeq; NP_388807.2; NC_000964.3.
DR   RefSeq; WP_010886456.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; P33189; -.
DR   SMR; P33189; -.
DR   STRING; 224308.BSU09260; -.
DR   jPOST; P33189; -.
DR   PaxDb; P33189; -.
DR   PRIDE; P33189; -.
DR   EnsemblBacteria; CAB12754; CAB12754; BSU_09260.
DR   GeneID; 939742; -.
DR   KEGG; bsu:BSU09260; -.
DR   PATRIC; fig|224308.43.peg.968; -.
DR   eggNOG; COG0161; Bacteria.
DR   InParanoid; P33189; -.
DR   OMA; YHGVNIA; -.
DR   PhylomeDB; P33189; -.
DR   BioCyc; BSUB:BSU09260-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0004015; F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity; IBA:GO_Central.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009102; P:biotin biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; Glycerol metabolism; Pyridoxal phosphate;
KW   Reference proteome; Transferase.
FT   CHAIN           1..450
FT                   /note="Uncharacterized aminotransferase YhxA"
FT                   /id="PRO_0000120535"
FT   MOD_RES         283
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        424..425
FT                   /note="QL -> HV (in Ref. 1; CAA65709 and 2; M99611)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   450 AA;  49877 MW;  89A11401ED9EC08F CRC64;
     MEMMGMENIQ QNQGLKQKDE QFVWHAMKGA HQADSLIAQK AEGAWVTDTD GRRYLDAMSG
     LWCVNIGYGR KELAEAAYEQ LKELPYYPLT QSHAPAIQLA EKLNEWLGGD YVIFFSNSGS
     EANETAFKIA RQYHLQNGDH SRYKFISRYR AYHGNTLGAL SATGQAQRKY KYEPLSQGFL
     HAAPPDIYRN PDDADTLESA NEIDRIMTWE LSETIAGVIM EPIITGGGIL MPPDGYMKKV
     EDICRRHGAL LICDEVICGF GRTGEPFGFM HYGVKPDIIT MAKGITSAYL PLSATAVKRD
     IFEAYQGEAP YDRFRHVNTF GGSPAACALA LKNLQIMEDE QLIQRSRDLG AKLLGELQAL
     REHPAVGDVR GKGLLIGIEL VKDKLTKEPA DAAKVNQVVA ACKEKGLIIG KNGDTVAGYN
     NVIQLAPPFC LTEEDLSFIV KTVKESFQTI