YHXC_BACSU
ID YHXC_BACSU Reviewed; 285 AA.
AC P40397; O07908;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Uncharacterized oxidoreductase YhxC;
DE EC=1.-.-.-;
DE AltName: Full=ORFX;
GN Name=yhxC; OrderedLocusNames=BSU10400;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 172-285.
RC STRAIN=E26;
RX PubMed=8196543; DOI=10.1111/j.1365-2958.1994.tb00347.x;
RA van Sinderen D., ten Berge A., Hayema B.J., Hamoen L., Venema G.;
RT "Molecular cloning and sequence of comK, a gene required for genetic
RT competence in Bacillus subtilis.";
RL Mol. Microbiol. 11:695-703(1994).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; Y14084; CAA74547.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12880.1; -; Genomic_DNA.
DR EMBL; S70734; AAB30863.1; -; Genomic_DNA.
DR PIR; D69835; D69835.
DR RefSeq; NP_388921.1; NC_000964.3.
DR RefSeq; WP_003245662.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P40397; -.
DR SMR; P40397; -.
DR STRING; 224308.BSU10400; -.
DR PaxDb; P40397; -.
DR PRIDE; P40397; -.
DR EnsemblBacteria; CAB12880; CAB12880; BSU_10400.
DR GeneID; 939316; -.
DR KEGG; bsu:BSU10400; -.
DR PATRIC; fig|224308.179.peg.1118; -.
DR eggNOG; COG1028; Bacteria.
DR InParanoid; P40397; -.
DR OMA; WEVANVI; -.
DR PhylomeDB; P40397; -.
DR BioCyc; BSUB:BSU10400-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..285
FT /note="Uncharacterized oxidoreductase YhxC"
FT /id="PRO_0000054844"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 45..69
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 177
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 196
FT /note="A -> R (in Ref. 3; AAB30863)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 285 AA; 30845 MW; BD361DB3F0DDCE6E CRC64;
MANQKKKTLP PQHQNQQPGF EYLMDPRPVF DKPKKAKKLE GKTAIITGGD SGIGRAVSVL
FAKEGANVVI VYLNEHQDAE ETKQYVEKEG VKCLLIAGDV GDEAFCNDVV GQASQVFPSI
DILVNNAAEQ HVQPSIEKIT SHQLIRTFQT NIFSMFYLTK AVLPHLKKGS SIINTASITA
YKGNKTLIDY SATKGAIVTF TRSLSQSLVQ QGIRVNAVAP GPIWTPLIPA SFAAKDVEVF
GSDVPMERPG QPVEVAPSYL YLASDDSTYV TGQTIHVNGG TIVNG
