YHXD_BACSU
ID YHXD_BACSU Reviewed; 299 AA.
AC P40398; O07554;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized oxidoreductase YhxD;
DE EC=1.-.-.-;
DE AltName: Full=ORFY;
GN Name=yhxD; OrderedLocusNames=BSU10430;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 160-299.
RC STRAIN=E26;
RX PubMed=8196543; DOI=10.1111/j.1365-2958.1994.tb00347.x;
RA van Sinderen D., ten Berge A., Hayema B.J., Hamoen L., Venema G.;
RT "Molecular cloning and sequence of comK, a gene required for genetic
RT competence in Bacillus subtilis.";
RL Mol. Microbiol. 11:695-703(1994).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; Y14081; CAA74462.1; -; Genomic_DNA.
DR EMBL; Y14084; CAA74549.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12883.1; -; Genomic_DNA.
DR EMBL; S70734; AAB30865.1; -; Genomic_DNA.
DR PIR; E69835; E69835.
DR RefSeq; NP_388924.1; NC_000964.3.
DR RefSeq; WP_003245421.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P40398; -.
DR SMR; P40398; -.
DR STRING; 224308.BSU10430; -.
DR PaxDb; P40398; -.
DR PRIDE; P40398; -.
DR EnsemblBacteria; CAB12883; CAB12883; BSU_10430.
DR GeneID; 939776; -.
DR KEGG; bsu:BSU10430; -.
DR PATRIC; fig|224308.179.peg.1121; -.
DR eggNOG; COG1028; Bacteria.
DR InParanoid; P40398; -.
DR OMA; AAYQMSQ; -.
DR PhylomeDB; P40398; -.
DR BioCyc; BSUB:BSU10430-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..299
FT /note="Uncharacterized oxidoreductase YhxD"
FT /id="PRO_0000054845"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 201
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 55..79
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 188
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 202
FT /note="A -> S (in Ref. 3; CAA74549/AAB30865)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 31909 MW; A448B38B5A4EA0D5 CRC64;
MSDSNLTNPI KAFFHDEFPE QYQEPPGLQK NMKPVPDCGE KSYKGSGKLT GRKALVTGGD
SGIGRAAAIA YAREGADVAI NYLPEEQPDA EEVKELIEAE GRKAVLIPGD LSDESFCQDL
VKQSHHELGG LDVLALVAGK QQAVENIEDL PTEQIYKTFE VNVFSLYWVV KAALPYLPEG
ASIITTTSVE GYNPSPMLLD YAATKNAIIG FTVGLGKQLA SKGIRVNSVA PGPIWTPLQI
SGGQPTENIP KFGQGTPPAP LNRAGQPVEL ADVYVFLASE NSSYVTSQVY GITGGIPTA
