YHY2_YEAST
ID YHY2_YEAST Reviewed; 785 AA.
AC P38870; D3DLD0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Uncharacterized protein YHR182W;
GN OrderedLocusNames=YHR182W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC P38870; P43603: LSB3; NbExp=2; IntAct=EBI-24848, EBI-22980;
CC -!- MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U00028; AAB68453.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06874.1; -; Genomic_DNA.
DR PIR; S46672; S46672.
DR RefSeq; NP_012052.1; NM_001179313.1.
DR AlphaFoldDB; P38870; -.
DR BioGRID; 36615; 61.
DR DIP; DIP-2718N; -.
DR IntAct; P38870; 4.
DR MINT; P38870; -.
DR STRING; 4932.YHR182W; -.
DR iPTMnet; P38870; -.
DR MaxQB; P38870; -.
DR PaxDb; P38870; -.
DR PRIDE; P38870; -.
DR EnsemblFungi; YHR182W_mRNA; YHR182W; YHR182W.
DR GeneID; 856588; -.
DR KEGG; sce:YHR182W; -.
DR SGD; S000001225; YHR182W.
DR VEuPathDB; FungiDB:YHR182W; -.
DR eggNOG; ENOG502R1XI; Eukaryota.
DR HOGENOM; CLU_356837_0_0_1; -.
DR InParanoid; P38870; -.
DR OMA; TFWSEDY; -.
DR BioCyc; YEAST:G3O-31213-MON; -.
DR PRO; PR:P38870; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38870; protein.
DR GO; GO:0005934; C:cellular bud tip; HDA:SGD.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..785
FT /note="Uncharacterized protein YHR182W"
FT /id="PRO_0000202935"
FT DOMAIN 520..702
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 313..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 785 AA; 90109 MW; 5C4399A8EEDF8435 CRC64;
MSVKEHNEED IIGDELQNSR QLSIDCDSVK ISLRNTYWTK DYTTGIKLFI KHMKRENDLL
IKDIKFYNDF VNKFWKPTLN NLQKMEATNS MNSRLLEVMS KQFNIISTEQ VERDCKIPLQ
ELRDLNESFL REAENDLSSR YSAYIKDLVA AKEALIGCEK RVQSIYKLKK ANTPVENSSS
VFDNGKDSAP LTRLNFVCEF PYTLDERLKF EDCDQFMSFL QTLKGKVILE KSVFSVPGLS
NQSFQGRSLI KELKKLEPRL NLSLFNIDRI GNEFIQLGII QEYSLSFYSS KVSQFDQEKY
YYWNSEVLAT QESNGNAGNR KKKSYGELTH SDNEHEEKSN VSSIKTSISD WIRKVSQHDN
DDCDAAGSTD MNKNEWKSLK QQLESSQDIF FSKCCQLEYS KVQLEKTIYD YCKNYSKMED
GIKRALESSN MMFQQKCEKF TDSPVCSLQE AQLPQETANA DVRGFFLRDN GIPFRRWNIL
EASDPVDACK EISIKSEKFF CGSEINNELA ALDTLGAIKI ILRQIEKEPN ANKVIQSWHR
DIDFVRVSNL KRDLLGEFKG SKTTENTNSI ITAHFFENSH SYVTNDLVGL IKLWLLELPD
SLIPSNHYDD LIKAEKSLTS LCEQFPTSSL RFLQELANHF QLINSKYSLP PQTIQDLFRD
NSDIDIPLAH HFVRRTGLQN PIDIKILSPT LSTFFINERT VETLQTLIAN RITTATTATL
TEPPTIIIKD TTAPIHSTPK PPPNDKDGHF IPRPFKTSST PTTPERPKRK SGLFLPINVN
DVPST
