YI14_SCHPO
ID YI14_SCHPO Reviewed; 881 AA.
AC Q9P7B3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Putative cation exchanger C521.04c;
GN ORFNames=SPAC521.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Putative cation exchanger. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CAB86468.1; -; Genomic_DNA.
DR RefSeq; NP_593099.1; NM_001018496.2.
DR AlphaFoldDB; Q9P7B3; -.
DR SMR; Q9P7B3; -.
DR BioGRID; 279765; 6.
DR STRING; 4896.SPAC521.04c.1; -.
DR iPTMnet; Q9P7B3; -.
DR MaxQB; Q9P7B3; -.
DR PaxDb; Q9P7B3; -.
DR PRIDE; Q9P7B3; -.
DR EnsemblFungi; SPAC521.04c.1; SPAC521.04c.1:pep; SPAC521.04c.
DR GeneID; 2543342; -.
DR KEGG; spo:SPAC521.04c; -.
DR PomBase; SPAC521.04c; -.
DR VEuPathDB; FungiDB:SPAC521.04c; -.
DR eggNOG; KOG1397; Eukaryota.
DR HOGENOM; CLU_001583_0_0_1; -.
DR InParanoid; Q9P7B3; -.
DR OMA; YQIYGSH; -.
DR PhylomeDB; Q9P7B3; -.
DR PRO; PR:Q9P7B3; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISM:PomBase.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503; PTHR31503; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF03733; YccF; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..881
FT /note="Putative cation exchanger C521.04c"
FT /id="PRO_0000317131"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 726..746
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 762..782
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 794..814
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 828..848
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 859..879
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 881 AA; 98858 MW; 4190EBFD883196C4 CRC64;
MSQPADINQS ESSAETITQG RRADRPEETP SSSVYEQNLR FGDFLMPTVG DADATDSLSQ
STNDRDIYSP REIDQYTRKV SSRTDPSTST ISNARQHPRN SVSRLSRSSS NVRQQRDIPK
QNFKVRPLSP LRGQSPASLR SEESFTLKER QNAINKTRAF GMRLWKPALY KKFRSINRDA
DIDIHDEPLK RPNTSISNVI WLICFGAPLF LVIFICYIFF TVLSFFNVPD AIVYSKLCRG
LMFYLLYPFG QHVRHKVKRL SVRSPAHPIY QTQHSHYDET PTSHHPDPAR LNFLSFSFCV
NPMNQSLDCN TTPHRRNASS IIYTLMYYLI IAPTLLITSA ICMFTIFFVP CARTLWAICR
HLRTCPLSLS FRPNLALPLS MDSSDVVLLC VKKAASWKYY KYTIDGIYII YFDMLALIIP
TIFFGFFGSQ GHWFTSSVFL FTASLVSIIP LAYFIGMAVA SISAQSSMGM GAFINAFFGS
VIEVFLYSVA LRKGNAGLVE GSVIGSILAG LLLMPGLSMC AGAIRKKFQF FNIKSAGATS
TMLLFAVLGA FAPTMLFRIY GPFRLDCEPC GANCQKCTKH YVLENDSLYK NRVLPFTYCC
SIMLVLAYAI GLWFTLRTHA SHIWQNFTAD DISFLKAEEE VGEPVNQDTA GNMSDSSEGG
EAVVNGNSQH HHNRDDASSG LSSNGSENES LEHEPTNELP QRPLVNQSQN SHGDDAPNWS
RSKSAIILLS ATFLYSLIAE ILVEHVDTVL DKFAISEKFL GLTLFALVPN TTEFMNAISF
ALNENIALSM EIGSAYALQV CLLQIPCLMG YSLFQYYRSG DSISFKHLFT MVFPTWDMIC
VMICVFLLTY VHSEGKSNYF KGSILVLAYL VSMLGFTFFN Y
