ID   YI167_YEAST             Reviewed;         210 AA.
AC   P0CF22; P17324; P40443; P40444; Q6Q579;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Putative truncated L-serine dehydratase SDL1;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase homolog 1;
GN   Name=SDL1; Synonyms=SDH1; OrderedLocusNames=YIL167W; ORFNames=YI9402.08B;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serine/threonine dehydratase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene unlikely to encode a
CC       functional protein. This is the C-terminal part of L-serine
CC       dehydratase. Strain S288c has a stop codon in position 128, which
CC       disrupts the gene coding for this protein and produces two ORFs YIL167W
CC       and YIL168W. Because of that it is not part of the S.cerevisiae S288c
CC       complete/reference proteome set. A contiguous sequence for L-serine
CC       dehydratase can be found in other strain backgrounds (AC P0CF23).
CC       {ECO:0000305|PubMed:24374639}.
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DR   EMBL; Z46921; CAA87025.1; -; Genomic_DNA.
DR   PIR; S12731; S12731.
DR   AlphaFoldDB; P0CF22; -.
DR   SMR; P0CF22; -.
DR   PRIDE; P0CF22; -.
DR   SGD; S000001429; SDL1.
DR   InParanoid; P0CF22; -.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; ISS:SGD.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009069; P:serine family amino acid metabolic process; ISS:SGD.
DR   Gene3D; 3.40.50.1100; -; 1.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
PE   5: Uncertain;
KW   Cytoplasm; Gluconeogenesis; Lyase; Pyridoxal phosphate.
FT   CHAIN           1..210
FT                   /note="Putative truncated L-serine dehydratase SDL1"
FT                   /id="PRO_0000393394"
SQ   SEQUENCE   210 AA;  22812 MW;  2D731889214FFB7E CRC64;
     MAQESQHGSK TLYVHPFDNE TIWEGHSTIV DEIIEQLKEN DISLPRVKAL VCSVGGGGLF
     SGIIKGLDRN QLAEKIPVVA VETAGCDVLN KSLKKGSPVT LEKLTSVATS LASPYIASFA
     FESFNKYGCK SVVLSDQDVL ATCLRYADDY NFIVEPACGA SLHLCYHPEI LEDILEQKIY
     EDDIVIIIAC GGSCMTYEDL VKASSTLNVS