YI31_SCHPO
ID YI31_SCHPO Reviewed; 601 AA.
AC Q9HE12;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Putative purine permease C1399.01c;
GN ORFNames=SPAC1399.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:16823372};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
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DR EMBL; CU329670; CAC19746.1; -; Genomic_DNA.
DR RefSeq; NP_593513.1; NM_001018947.2.
DR AlphaFoldDB; Q9HE12; -.
DR SMR; Q9HE12; -.
DR BioGRID; 278915; 5.
DR STRING; 4896.SPAC1399.01c.1; -.
DR PaxDb; Q9HE12; -.
DR EnsemblFungi; SPAC1399.01c.1; SPAC1399.01c.1:pep; SPAC1399.01c.
DR GeneID; 2542454; -.
DR KEGG; spo:SPAC1399.01c; -.
DR PomBase; SPAC1399.01c; -.
DR VEuPathDB; FungiDB:SPAC1399.01c; -.
DR eggNOG; ENOG502QQD4; Eukaryota.
DR HOGENOM; CLU_017959_7_0_1; -.
DR InParanoid; Q9HE12; -.
DR OMA; RKSAPFF; -.
DR PhylomeDB; Q9HE12; -.
DR PRO; PR:Q9HE12; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042907; F:xanthine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1904082; P:pyrimidine nucleobase transmembrane transport; ISM:PomBase.
DR GO; GO:0042906; P:xanthine transport; IBA:GO_Central.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR TIGRFAMs; TIGR00801; ncs2; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Vacuole.
FT CHAIN 1..601
FT /note="Putative purine permease C1399.01c"
FT /id="PRO_0000316576"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 601 AA; 64572 MW; C645680B07778F0E CRC64;
MSESIQDQDH EKTTIIEKTR RFVLSIFTKD FWIGDYDYSF LLPAIPFTKQ KPKSPPFFSL
NAKVPVLLAL LLGFQHALAM VGGVTSPPRI IAASANLTTE QTNYLVSAGL ISSGIMTLIQ
IARVHIPKTK YYIGTGMLSV LGISFTSVSV APKVLSQMYE NGYCPKDENG TKLPCPDGYG
AFLATACVCS LLEIFMSFIP PRILKRLFPP IVTGPVVLLI GTSLISSGLN DWAGGEGSCT
GRPTEAEAPG YSLCPSDTSP HALGWGSAQF IGLGFSVFAT IIIIERFGPP LMKTTSVVLG
LVVGMIISAA TGYWDHSIID AAPVVTFNWV HTFRLRIYGP AVLPMLALYI VNMMEAIGDI
GATSDVSMLE VDGPAFDARV QGGILGDGLA SLIASLMTTT PLTTFAQNNG VISLTKCANR
RAGFFCAVIL FFMGLFAKFA AVFVAIPSPV LGGMTTFLFS SVAVSGIAII SQIPFNRRNR
FILTASMTLG MGAILVPDWF TYFFEYSGPN KALVGFLDAI TLVMENGFAI GAFISIFLNL
ILPYEFDPDL TNDSPGLSTT NGVNNGIVEV RGIDPNDSLS NTDTEYANEN KKDEVDVDKV
V
