YI7H_SCHPO
ID YI7H_SCHPO Reviewed; 598 AA.
AC Q9P7T9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized membrane protein C977.17;
GN ORFNames=SPAC977.17;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA).
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB69639.1; -; Genomic_DNA.
DR PIR; T50288; T50288.
DR RefSeq; NP_592788.1; NM_001018188.2.
DR AlphaFoldDB; Q9P7T9; -.
DR SMR; Q9P7T9; -.
DR BioGRID; 279726; 41.
DR STRING; 4896.SPAC977.17.1; -.
DR iPTMnet; Q9P7T9; -.
DR PaxDb; Q9P7T9; -.
DR EnsemblFungi; SPAC977.17.1; SPAC977.17.1:pep; SPAC977.17.
DR GeneID; 2543301; -.
DR KEGG; spo:SPAC977.17; -.
DR PomBase; SPAC977.17; -.
DR VEuPathDB; FungiDB:SPAC977.17; -.
DR eggNOG; KOG0224; Eukaryota.
DR HOGENOM; CLU_020019_2_1_1; -.
DR InParanoid; Q9P7T9; -.
DR OMA; YPEDLHP; -.
DR PhylomeDB; Q9P7T9; -.
DR Reactome; R-SPO-432030; Transport of glycerol from adipocytes to the liver by Aquaporins.
DR Reactome; R-SPO-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-SPO-432047; Passive transport by Aquaporins.
DR PRO; PR:Q9P7T9; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; ISM:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015254; F:glycerol channel activity; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR GO; GO:0015793; P:glycerol transmembrane transport; IBA:GO_Central.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR TIGRFAMs; TIGR00861; MIP; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..598
FT /note="Uncharacterized membrane protein C977.17"
FT /id="PRO_0000310367"
FT TOPO_DOM 1..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..346
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 368..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 410..444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..473
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 495..532
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 554..598
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 371..373
FT /note="NPA 1"
FT MOTIF 501..503
FT /note="NPA 2"
FT COMPBIAS 139..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 65816 MW; 182AC74BFC1CD079 CRC64;
MSVPLRFSTP SSSPSASDNE SVHDDGPTTE LDTFNTTDVP RRVNTTKARQ MRPKNTLKVA
FSSPNLKGLD NTADSDSQPW LGGYLAGRLE DISGQSRRNY VDPYYEELNA GRRPNKPVWS
LNGPLPHVLG NSVVEKISQK NQEARSRANS RVNSRANSRA NSSVSLAGMD GSPNWKRKMK
SAVFGSRVKL NDEEAQLPRN KSSVSIAEQA ASRPKVSFSL QSSRQPSIAE EQPQTQRKSS
AITVEHAENA EPETPRNNVS FSRKPSIAEQ DSSQDITMPP NEIIAEESLD SGSDTETLYL
NYWCKIRHFF REGFAEFLGT LVLVVFGVGS NLQATVTNGA GGSFESLSFA WGFGCMLGVY
IAGGISGGHV NPAVTISLAI FRKFPWYKVP IYIFFQIWGA FFGGALAYGY HWSSITEFEG
GKDIRTPATG GCLYTNPKPY VTWRNAFFDE FIGTAVLVGC LFAILDDTNS PPTQGMTAFI
VGLLIAAIGM ALGYQTSFTL NPARDLGPRM FAWWIGYGPH SFHLYHWWWT WGAWGGTIGG
GIAGGLIYDL VIFTGPESPL NYPDNGFIDK KVHQITAKFE KEEEVENLEK TDSPIENN
