ID   CBID_CLOD6              Reviewed;         408 AA.
AC   Q180S8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Cobalt-precorrin-5B C(1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_00787};
DE            EC=2.1.1.195 {ECO:0000255|HAMAP-Rule:MF_00787};
DE   AltName: Full=Cobalt-precorrin-6A synthase {ECO:0000255|HAMAP-Rule:MF_00787};
GN   Name=cbiD {ECO:0000255|HAMAP-Rule:MF_00787}; OrderedLocusNames=CD630_34290;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to
CC       form cobalt-precorrin-6A. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A +
CC         S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26285, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:60063, ChEBI:CHEBI:60064;
CC         EC=2.1.1.195; Evidence={ECO:0000255|HAMAP-Rule:MF_00787};
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 6/10. {ECO:0000255|HAMAP-Rule:MF_00787}.
CC   -!- SIMILARITY: Belongs to the CbiD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00787}.
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DR   EMBL; AM180355; CAJ70332.1; -; Genomic_DNA.
DR   RefSeq; WP_011861964.1; NZ_CP010905.2.
DR   RefSeq; YP_001089949.1; NC_009089.1.
DR   AlphaFoldDB; Q180S8; -.
DR   SMR; Q180S8; -.
DR   STRING; 272563.CD630_34290; -.
DR   EnsemblBacteria; CAJ70332; CAJ70332; CD630_34290.
DR   KEGG; cdf:CD630_34290; -.
DR   KEGG; pdc:CDIF630_03737; -.
DR   PATRIC; fig|272563.120.peg.3623; -.
DR   eggNOG; COG1903; Bacteria.
DR   OMA; YHGKLIK; -.
DR   PhylomeDB; Q180S8; -.
DR   BioCyc; PDIF272563:G12WB-3606-MON; -.
DR   UniPathway; UPA00148; UER00227.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0043780; F:cobalt-precorrin-5B C1-methyltransferase activity; IEA:RHEA.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046140; P:corrin biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2110.10; -; 1.
DR   HAMAP; MF_00787; CbiD; 1.
DR   InterPro; IPR002748; CbiD.
DR   InterPro; IPR036074; CbiD_sf.
DR   PANTHER; PTHR35863; PTHR35863; 1.
DR   Pfam; PF01888; CbiD; 1.
DR   PIRSF; PIRSF026782; CbiD; 1.
DR   SUPFAM; SSF111342; SSF111342; 1.
DR   TIGRFAMs; TIGR00312; cbiD; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..408
FT                   /note="Cobalt-precorrin-5B C(1)-methyltransferase"
FT                   /id="PRO_0000257756"
SQ   SEQUENCE   408 AA;  45430 MW;  F349930F08E053D2 CRC64;
     MEEYVYIDGK KYRRGYTTGS CATGASKAAV YMLITKNRIN TINIDTPKGI PLLLKVDNIN
     ISDTFVECSI KKDGGDDIDA THTMDIYARA EIVAKNDKNK GYLTLKDIDS LSTNSECKSE
     LYKFIRVYGG TGIGVVTKKG LSVDVGKPAI NPTPLKMINH EIRKLIGDNF ESILGNDKVL
     KITIFAPQGE TVAKKTFNPR LGIVGGISII GTTGIVEPMS DDGWKKSLSI ELQMKKEQGL
     DKIILVPGNH GEQFIREKLN LDIKYVVRVS NFIGYMIKEA QRIGYKKILM AGHIGKFIKV
     SAGIFNTHSK VADARSEILV ANLALMGARY EFLNKINQCV TTEEAVELIN NSEYREVYNI
     LSNKCRERVK QYLNEDSDDI DVEVIIFSMD KSLLGKSDNT DDLVEVFI