YICJ_ECOLI
ID YICJ_ECOLI Reviewed; 460 AA.
AC P31435; P76724; Q2M7X0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Inner membrane symporter YicJ;
GN Name=yicJ; OrderedLocusNames=b3657, JW5939;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT organizational symmetry around the origin of replication.";
RL Genomics 16:551-561(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA62010.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L10328; AAA62010.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76681.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77636.1; -; Genomic_DNA.
DR RefSeq; NP_418114.4; NC_000913.3.
DR RefSeq; WP_000834439.1; NZ_STEB01000024.1.
DR AlphaFoldDB; P31435; -.
DR SMR; P31435; -.
DR BioGRID; 4261976; 177.
DR STRING; 511145.b3657; -.
DR TCDB; 2.A.2.3.4; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR PaxDb; P31435; -.
DR PRIDE; P31435; -.
DR EnsemblBacteria; AAC76681; AAC76681; b3657.
DR EnsemblBacteria; BAE77636; BAE77636; BAE77636.
DR GeneID; 66672447; -.
DR GeneID; 948168; -.
DR KEGG; ecj:JW5939; -.
DR KEGG; eco:b3657; -.
DR PATRIC; fig|511145.12.peg.3777; -.
DR EchoBASE; EB1637; -.
DR eggNOG; COG2211; Bacteria.
DR HOGENOM; CLU_027408_0_2_6; -.
DR InParanoid; P31435; -.
DR OMA; GLYTAWM; -.
DR PhylomeDB; P31435; -.
DR BioCyc; EcoCyc:YICJ-MON; -.
DR PRO; PR:P31435; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001927; Na/Gal_symport.
DR InterPro; IPR018043; Na/Gal_symport_CS.
DR PANTHER; PTHR11328; PTHR11328; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00792; gph; 1.
DR PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..460
FT /note="Inner membrane symporter YicJ"
FT /id="PRO_0000170766"
FT TOPO_DOM 1..11
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..80
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..116
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..152
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..248
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..403
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 50948 MW; BBDDC8BC7D2D2B13 CRC64;
MKSEVLSVKE KIGYGMGDAA SHIIFDNVML YMMFFYTDIF GIPAGFVGTM FLVARALDAI
SDPCMGLLAD RTRSRWGKFR PWVLFGALPF GIVCVLAYST PDLSMNGKMI YAAITYTLLT
LLYTVVNIPY CALGGVITND PTQRISLQSW RFVLATAGGM LSTVLMMPLV NLIGGDNKPL
GFQGGIAVLS VVAFMMLAFC FFTTKERVEA PPTTTSMRED LRDIWQNDQW RIVGLLTIFN
ILAVCVRGGA MMYYVTWILG TPEVFVAFLT TYCVGNLIGS ALAKPLTDWK CKVTIFWWTN
ALLAVISLAM FFVPMQASIT MFVFIFVIGV LHQLVTPIQW VMMSDTVDYG EWCNGKRLTG
ISFAGTLFVL KLGLAFGGAL IGWMLAYGGY DAAEKAQNSA TISIIIALFT IVPAICYLLS
AIIAKRYYSL TTHNLKTVME QLAQGKRRCQ QQFTSQEVQN
