YICL_ECOLI
ID YICL_ECOLI Reviewed; 307 AA.
AC P31437; Q2M7X2;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Uncharacterized inner membrane transporter YicL;
GN Name=yicL; OrderedLocusNames=b3660, JW3634;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT organizational symmetry around the origin of replication.";
RL Genomics 16:551-561(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
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DR EMBL; L10328; AAA62012.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76683.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77634.1; -; Genomic_DNA.
DR PIR; E65167; E65167.
DR RefSeq; NP_418116.1; NC_000913.3.
DR RefSeq; WP_000535961.1; NZ_SSZK01000043.1.
DR AlphaFoldDB; P31437; -.
DR SMR; P31437; -.
DR BioGRID; 4259627; 17.
DR STRING; 511145.b3660; -.
DR TCDB; 2.A.7.3.12; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; P31437; -.
DR PRIDE; P31437; -.
DR EnsemblBacteria; AAC76683; AAC76683; b3660.
DR EnsemblBacteria; BAE77634; BAE77634; BAE77634.
DR GeneID; 948176; -.
DR KEGG; ecj:JW3634; -.
DR KEGG; eco:b3660; -.
DR PATRIC; fig|1411691.4.peg.3046; -.
DR EchoBASE; EB1639; -.
DR eggNOG; COG0697; Bacteria.
DR HOGENOM; CLU_033863_19_0_6; -.
DR InParanoid; P31437; -.
DR OMA; GVQAFYF; -.
DR PhylomeDB; P31437; -.
DR BioCyc; EcoCyc:EG11688-MON; -.
DR PRO; PR:P31437; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR004779; CO/AA/NH_transpt.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
DR TIGRFAMs; TIGR00950; 2A78; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..307
FT /note="Uncharacterized inner membrane transporter YicL"
FT /id="PRO_0000108173"
FT TOPO_DOM 1..7
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..71
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..124
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..184
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..263
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 16..145
FT /note="EamA 1"
FT DOMAIN 167..291
FT /note="EamA 2"
SQ SEQUENCE 307 AA; 33113 MW; 9EEAF9067FFCABD5 CRC64;
MGSTRKGMLN VLIAAVLWGS SGVCAQYIME QSQMSSQFLT MTRLIFAGLI LLTLSFVHGD
KIFSIINNHK DAISLLIFSV VGALTVQLTF LLTIEKSNAA TATVLQFLSP TIIVAWFSLV
RKSRPGILVF CAILTSLVGT FLLVTHGNPT SLSISPAALF WGIASAFAAA FYTTYPSTLI
ARYGTLPVVG WSMLIGGLIL LPFYARQGTN FVVNGSLILA FFYLVVIGTS LTFSLYLKGA
QLIGGPKASI LSCAEPLSSA LLSLLLLGIT FTLPDWLGTL LILSSVILIS MDSRRRARKI
NRPARHK
