ID   YICL_SALTY              Reviewed;         300 AA.
AC   O33787;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Uncharacterized inner membrane transporter YicL;
GN   Name=yicL; OrderedLocusNames=STM3765;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-246.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9311997; DOI=10.1093/emboj/16.17.5376;
RA   Blanc-Potard A.-B., Groisman E.A.;
RT   "The Salmonella selC locus contains a pathogenicity island mediating
RT   intramacrophage survival.";
RL   EMBO J. 16:5376-5385(1997).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL22623.1; -; Genomic_DNA.
DR   EMBL; AJ000509; CAA04143.1; -; Genomic_DNA.
DR   RefSeq; NP_462664.1; NC_003197.2.
DR   RefSeq; WP_001682335.1; NC_003197.2.
DR   AlphaFoldDB; O33787; -.
DR   SMR; O33787; -.
DR   STRING; 99287.STM3765; -.
DR   PaxDb; O33787; -.
DR   EnsemblBacteria; AAL22623; AAL22623; STM3765.
DR   GeneID; 1255289; -.
DR   KEGG; stm:STM3765; -.
DR   PATRIC; fig|99287.12.peg.3984; -.
DR   HOGENOM; CLU_033863_19_0_6; -.
DR   OMA; GVQAFYF; -.
DR   PhylomeDB; O33787; -.
DR   BioCyc; SENT99287:STM3765-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..300
FT                   /note="Uncharacterized inner membrane transporter YicL"
FT                   /id="PRO_0000108174"
FT   TOPO_DOM        1..7
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..45
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..71
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..124
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        173..184
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..263
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..300
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          16..145
FT                   /note="EamA 1"
FT   DOMAIN          167..291
FT                   /note="EamA 2"
SQ   SEQUENCE   300 AA;  32211 MW;  E16E4F970092F0BC CRC64;
     MGSTRKGMLN VLIAAVLWGS SGVCAQYIME QSRMSSQFLT MIRLLFAGLI LVTFSFMHGD
     KIFSILKNRK DALSLLIFSV VGALTVQLTF LLTIEKSNAA TATVLQFLSP TIIVAWFALA
     RRTRPGILVL TAILTSLIGT FLLVTHGNPT SLSISSAALF WGIASAFAAA FYTTWPSRLI
     AQYGTLPVVG WSMSFGGLIL LPFYAKEGTH FAVSGSLILA FFYLVVIGTS LTFSLYLKGA
     QLIGGPKASI LSCAEPLSSA LLSLLLLGIS FTLPDWLGTL LILSSVILIS LDSRRRARAA