YICR_ECOLI
ID YICR_ECOLI Reviewed; 222 AA.
AC P25531; Q2M7V2;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 3.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=UPF0758 protein YicR;
GN Name=yicR; OrderedLocusNames=b3638, JW5643;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7686882; DOI=10.1006/geno.1993.1230;
RA Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.;
RT "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome:
RT organizational symmetry around the origin of replication.";
RL Genomics 16:551-561(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-222.
RC STRAIN=K12;
RX PubMed=1741263; DOI=10.1093/nar/20.2.366;
RA Felzenszwalb I., Boiteux S., Laval J.;
RT "Identification of the radC102 mutation. Order of the genes in the 81.5-
RT 82.0 min region of the Escherichia coli chromosome.";
RL Nucleic Acids Res. 20:366-366(1992).
RN [5]
RP SHOWS THAT THIS IS NOT RADC.
RX PubMed=11053371; DOI=10.1128/jb.182.22.6287-6291.2000;
RA Lombardo M.J., Rosenberg S.M.;
RT "radC102 of Escherichia coli is an allele of recG.";
RL J. Bacteriol. 182:6287-6291(2000).
CC -!- SIMILARITY: Belongs to the UPF0758 family. YicR subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be the site of the radC102 mutation,
CC but it was subsequently shown that radC102 is an allele of RecG.
CC {ECO:0000305|PubMed:11053371}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA61991.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L10328; AAA61991.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76662.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77654.1; -; Genomic_DNA.
DR EMBL; X63366; CAA44966.1; -; Genomic_DNA.
DR EMBL; X63367; CAA44967.1; -; Genomic_DNA.
DR PIR; H65164; H65164.
DR RefSeq; NP_418095.4; NC_000913.3.
DR RefSeq; WP_001350561.1; NZ_LN832404.1.
DR AlphaFoldDB; P25531; -.
DR SMR; P25531; -.
DR BioGRID; 4261656; 200.
DR DIP; DIP-10636N; -.
DR IntAct; P25531; 2.
DR STRING; 511145.b3638; -.
DR PaxDb; P25531; -.
DR PRIDE; P25531; -.
DR EnsemblBacteria; AAC76662; AAC76662; b3638.
DR EnsemblBacteria; BAE77654; BAE77654; BAE77654.
DR GeneID; 948968; -.
DR KEGG; ecj:JW5643; -.
DR KEGG; eco:b3638; -.
DR PATRIC; fig|511145.12.peg.3758; -.
DR EchoBASE; EB1288; -.
DR eggNOG; COG2003; Bacteria.
DR HOGENOM; CLU_073529_0_1_6; -.
DR InParanoid; P25531; -.
DR OMA; AMPDYEL; -.
DR PhylomeDB; P25531; -.
DR BioCyc; EcoCyc:EG11312-MON; -.
DR PRO; PR:P25531; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd08071; MPN_DUF2466; 1.
DR HAMAP; MF_00018; UPF0758_YicR; 1.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR025657; RadC_JAB.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001405; UPF0758.
DR InterPro; IPR020891; UPF0758_CS.
DR InterPro; IPR022820; UPF0758_YicR.
DR PANTHER; PTHR30471; PTHR30471; 1.
DR Pfam; PF04002; RadC; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR TIGRFAMs; TIGR00608; radc; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS01302; UPF0758; 1.
PE 3: Inferred from homology;
KW Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW Zinc.
FT CHAIN 1..222
FT /note="UPF0758 protein YicR"
FT /id="PRO_0000190694"
FT DOMAIN 100..222
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT MOTIF 171..184
FT /note="JAMM motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 171
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 173
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT BINDING 184
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 222 AA; 25343 MW; 1E825DEB596D742A CRC64;
MKNNSQLLMP REKMLKFGIS ALTDVELLAL FLRTGTRGKD VLTLAKEMLE NFGSLYGLLT
SEYEQFSGVH GIGVAKFAQL KGIAELARRY YNVRMREESP LLSPEMTREF LQSQLTGEER
EIFMVIFLDS QHRVITHRRL FSGTLNHVEV HPREIIREAI KINASALILA HNHPSGCAEP
SKADKLITER IIKSCQFMDL RVLDHIVIGR GEYVSFAERG WI
