YIDC1_LACPL
ID YIDC1_LACPL Reviewed; 307 AA.
AC Q88WR8; F9UNT3;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Membrane protein insertase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC 1 {ECO:0000255|HAMAP-Rule:MF_01811};
DE Flags: Precursor;
GN Name=yidC1 {ECO:0000255|HAMAP-Rule:MF_01811}; OrderedLocusNames=lp_1553;
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01811}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01811}.
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DR EMBL; AL935263; CCC78872.1; -; Genomic_DNA.
DR RefSeq; WP_011101463.1; NC_004567.2.
DR RefSeq; YP_004889386.1; NC_004567.2.
DR AlphaFoldDB; Q88WR8; -.
DR SMR; Q88WR8; -.
DR STRING; 220668.lp_1553; -.
DR EnsemblBacteria; CCC78872; CCC78872; lp_1553.
DR KEGG; lpl:lp_1553; -.
DR PATRIC; fig|220668.9.peg.1306; -.
DR eggNOG; COG0706; Bacteria.
DR HOGENOM; CLU_036138_5_1_9; -.
DR OMA; GWAIIII; -.
DR PhylomeDB; Q88WR8; -.
DR BioCyc; LPLA220668:G1GW0-1333-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Protein transport; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT CHAIN 23..307
FT /note="Membrane protein insertase YidC 1"
FT /id="PRO_0000020384"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT REGION 260..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 23
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
FT LIPID 23
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01811"
SQ SEQUENCE 307 AA; 34248 MW; B425049E09D49154 CRC64;
MKSKKGLTLT ITLGTLALFL SGCVQTTKAG KPYGFVYEYL AKPGQNVMEW LSQLFGNNYG
WAIIGLTVIV RLVLLPMMIN QQRKSTYQQE KMSAVRPQME KIQARQKAAT TQEEKAAISN
ELMQLYRDNG ISMTGGIGCL PLLIQLPIFS ALYYAIRYSP ELSKATFMGI SLGKSSLILA
ILAFLSYLAQ GYLSMIGLPE EQKKTMRLML IMSPVMILFV SMSAPAGLGL YFFVGGLFAC
LQTLIINFFR PRIRREVEAE LKKHPIKTPT PTQPKPINAT ESKPSHPRPQ NNAGRGRNAG
KQQRHHK
